DECANOIC-2,2-D2 ACID

Base Information

• Chemical Name: DECANOIC-2,2-D2 ACID
• CAS No.: 62716-49-8
• Molecular Formula: C10H18D2O2
• Molecular Weight: 174.28
• Mol file: 62716-49-8.mol

Synonyms:DECANOIC-2,2-D2 ACID

Chemical Property of DECANOIC-2,2-D2 ACID

Chemical Property:

• PSA: 37.30000
• LogP: 3.21170

Purity/Quality:

98% ^*data from raw suppliers

Decanoic-2,2-d2Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Decanoic acid-d2 is intended for use as an internal standard for the quantification of decanoic acid by GC- or LC-MS. Decanoic acid is a medium-chain saturated fatty acid. It is a non-competitive antagonist at AMPA receptors that selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1 and GluA2 subunits (IC50 = 1.16 mM). It inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices. Decanoic acid (1 mM) induces contractions in isolated guinea pig duodenum, an effect that can be blocked by the muscarinic acetylcholine receptor antagonist hyoscine, voltage-gated sodium channel inhibitor tetrodotoxin (Item Nos. 14964 | 14963), or M2 muscarinic acetylcholine receptor antagonist hexamethonium . It increases the escape threshold in an orofacial mechanical stimulation test in rats when administered at a topical dose of 30% in ointment form, indicating analgesic activity. This effect can be blocked by the muscarinic acetylcholine receptor antagonist methoctramine . Plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer.
• Uses: Decanoic-2,2-d2 Acid (CAS# 62716-49-8) is a useful isotopically labeled research compound.

Technology Process of DECANOIC-2,2-D2 ACID

There total 3 articles about DECANOIC-2,2-D2 ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

diethyl octylmalonate (1472-85-1) → α-deuterated decanoic acid (62716-49-8)

Guidance literature:

With water-d2; hydrogen chloride; for 192h; Reflux;

DOI:10.1039/c002509g

Reference yield:

1-decanoic acid (334-48-5) → α-deuterated decanoic acid (62716-49-8)

Guidance literature:

With deuteriated sodium hydroxide; at 200 ℃; for 72h;

DOI:10.1021/j150667a031

Reference yield:

→ α-deuterated decanoic acid (62716-49-8)

Guidance literature:

Na-Salz der undeuterierten Saeure, D2O-NaOD;

DOI:10.1007/BF02532978

upstream raw materials:

1-decanoic acid

diethyl octylmalonate