Carbamic acid, [(1S,3Z)-1-(hydroxymethyl)-3-pentenyl]-, 1,1-dimethylethyl

Base Information

• Chemical Name: Carbamic acid, [(1S,3Z)-1-(hydroxymethyl)-3-pentenyl]-, 1,1-dimethylethyl
• CAS No.: 666719-09-1
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.28934
• Mol file: 666719-09-1.mol

Synonyms:Carbamic acid, [(1S,3Z)-1-(hydroxymethyl)-3-pentenyl]-, 1,1-dimethylethyl

Chemical Property of Carbamic acid, [(1S,3Z)-1-(hydroxymethyl)-3-pentenyl]-, 1,1-dimethylethyl

Chemical Property:

• PSA: 58.56000
• LogP: 2.22910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1S,3Z)-1-(hydroxymethyl)-3-pentenyl]-, 1,1-dimethylethyl

There total 4 articles about Carbamic acid, [(1S,3Z)-1-(hydroxymethyl)-3-pentenyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(1-hydroxymethyl-pent-3-ynyl)-carbamic acid tert-butyl ester (666719-08-0) → ((Z)-(S)-1-Hydroxymethyl-pent-3-enyl)-carbamic acid tert-butyl ester (666719-09-1)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethanol;

DOI:10.1016/j.bmcl.2003.09.088

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → ((Z)-(S)-1-Hydroxymethyl-pent-3-enyl)-carbamic acid tert-butyl ester (666719-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / dioxane; H₂O

2: 83 percent / H₂ / Lindlar's catalyst / ethanol

With hydrogen; sodium carbonate; Lindlar's catalyst; In 1,4-dioxane; ethanol; water; 2: Lindlar hydrogenation;

DOI:10.1016/j.bmcl.2003.09.088

Reference yield:

(S)-2-Amino-hex-4-yn-1-ol → ((Z)-(S)-1-Hydroxymethyl-pent-3-enyl)-carbamic acid tert-butyl ester (666719-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / dioxane; H₂O

2: 83 percent / H₂ / Lindlar's catalyst / ethanol

With hydrogen; sodium carbonate; Lindlar's catalyst; In 1,4-dioxane; ethanol; water; 2: Lindlar hydrogenation;

DOI:10.1016/j.bmcl.2003.09.088

upstream raw materials:

(1-hydroxymethyl-pent-3-ynyl)-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

4-but-2-ynyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

((Z)-(S)-1-Formyl-pent-3-enyl)-carbamic acid tert-butyl ester

Refernces