2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID
• CAS No.: 668484-45-5
• Molecular Formula: C13H19N3O4S
• Molecular Weight: 313.378
• Hs Code.: 2934100090
• Mol file: 668484-45-5.mol

Synonyms:2-(PIPERDIN-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, N1-BOC PROTECTED;2-[1-(TERT-BUTOXYCARBONYL)PIPERDIN-4-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(tert-butoxycarbonyl)piperid-4-yl]-1,3-thiazole-4-carboxylic acid

Chemical Property of 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.04E-09mmHg at 25°C
• Melting Point: 162 °C
• Refractive Index: 1.563
• Boiling Point: 0°C
• PKA: 1.35±0.10(Predicted)
• Flash Point: 0°C
• PSA: 107.97000
• Density: 1.279g/cm³
• LogP: 2.89370
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylicacid 98% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID

There total 3 articles about 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(4-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester (867065-53-0) → 2-(4-[(tert-butoxy)carbonyl]piperazin-1-yl)-1,3-thiazole-4-carboxylic acid (668484-45-5)

Guidance literature:

With ethanol; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield: 88.7%

→ 2-(4-[(tert-butoxy)carbonyl]piperazin-1-yl)-1,3-thiazole-4-carboxylic acid (668484-45-5)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; for 0.333333h;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → 2-(4-[(tert-butoxy)carbonyl]piperazin-1-yl)-1,3-thiazole-4-carboxylic acid (668484-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 100 °C

2: sodium hydroxide; ethanol / tetrahydrofuran / 2 h / 60 °C

With ethanol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

1-t-Butoxycarbonylpiperazine

4-(4-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester

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