2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole

Base Information

Chemical Name:2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole
CAS No.:70006-24-5
Molecular Formula:C17H19N5
Molecular Weight:402.74908
Hs Code.:2933599590
UNII:4WV2575JWT
ChEMBL ID:CHEMBL440687
DSSTox Substance ID:DTXSID001025592
Nikkaji Number:J2.074.623H
Pharos Ligand ID:R4KQZL7JJM3L
Wikidata:Q4650426
Wikipedia:ABT-724
Mol file:70006-24-5.mol

Synonyms:2-((4-pyridin-2-ylpiperazine-1-yl)methyl)-1H-benzimidazole;ABT-724;ABT724

Suppliers and Price of 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ABT724
50mg
$ 100.00

Tocris
ABT-724 trihydrochloride ≥99%(HPLC)
10
$ 144.00

Tocris
ABT-724 trihydrochloride ≥99%(HPLC)
50
$ 603.00

Sigma-Aldrich
ABT-724 trihydrochloride ≥98% (HPLC)
25 mg
$ 396.00

Sigma-Aldrich
ABT-724 trihydrochloride ≥98% (HPLC)
5 mg
$ 101.00

CSNpharm
ABT-724
10mg
$ 70.00

CSNpharm
ABT-724
25mg
$ 100.00

CSNpharm
ABT-724
1mg
$ 29.00

CSNpharm
ABT-724
100mg
$ 300.00

American Custom Chemicals Corporation
ABT-724 95.00%
50MG
$ 1170.31

Total 19 raw suppliers

Chemical Property of 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole

Chemical Property:

Vapor Pressure:4.36E-12mmHg at 25°C
Refractive Index:1.687
Boiling Point:548.6°C at 760 mmHg
Flash Point:285.6°C
PSA：48.05000
Density:1.275g/cm³
LogP:2.28300
Storage Temp.:Desiccate at +4°C
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:293.16404563
Heavy Atom Count:22
Complexity:355

Purity/Quality:

99%, ^*data from raw suppliers

ABT724 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CC2=NC3=CC=CC=C3N2)C4=CC=CC=N4
Uses ABT 724 trihydrochloride is a potent dopamine D4 receptor agonist. ABT 724 is used in pharmacology systems for treating ocular disorders.

Technology Process of 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole

There total 2 articles about 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 34803-66-2
1-(2-pyridyl)piperazine

: 70006-24-5
ABT-724

Guidance literature:: With triethylamine; In 2-chloromethyl-1H-benzimidazole; water; N,N-dimethyl-formamide;

Reference yield: 72.0%

: 4857-04-9
2-chloromethyl-1H-benzimidazole

: 34803-66-2
1-(2-pyridyl)piperazine

: 70006-24-5
ABT-724

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm030505a

Reference yield: 68.0%

: 620-05-3
iodomethylbenzene

: 70006-24-5
ABT-724

: 1-benzyl-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-benzoimidazole

Guidance literature:: ABT-724; With sodium hexamethyldisilazane; In tetrahydrofuran; at 23 ℃; for 0.166667h;

iodomethylbenzene; In tetrahydrofuran; for 12h;
DOI:10.1021/jm030505a