(1S,2S)-(+)-1,2-Bis(diphenylphosphinomethyl)cyclohexane

Base Information

Chemical Name:(1S,2S)-(+)-1,2-Bis(diphenylphosphinomethyl)cyclohexane
CAS No.:70223-77-7
Molecular Formula:C32H34P2
Molecular Weight:480.569
Hs Code.:
DSSTox Substance ID:DTXSID20505183
Nikkaji Number:J922.959K
Mol file:70223-77-7.mol

Synonyms:70223-77-7;(1S,2S)-(+)-1,2-BIS(DIPHENYLPHOSPHINOMETHYL)CYCLOHEXANE;(S,S)-1,2-Bis(diphenylphosphinomethyl)cyclohexane;[(1S,2S)-2-(diphenylphosphanylmethyl)cyclohexyl]methyl-diphenylphosphane;1,1'-[(1S,2S)-1,2-Cyclohexanediylbis(methylene)]bis[1,1-diphenylphosphine];SCHEMBL3958144;DTXSID20505183;CS-0088694;((1s,2s)-trans-1,2-bis(diphenylphosphinomethyl)cyclohexane);[(1S,2S)-Cyclohexane-1,2-diylbis(methylene)]bis(diphenylphosphane)

Suppliers and Price of (1S,2S)-(+)-1,2-Bis(diphenylphosphinomethyl)cyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(1S,2S)-(+)-1,2-BIS(DIPHENYLPHOSPHINOMETHYL)CYCLOHEXANE 95.00%
5MG
$ 505.33

Total 6 raw suppliers

Chemical Property of (1S,2S)-(+)-1,2-Bis(diphenylphosphinomethyl)cyclohexane

Chemical Property:

Boiling Point:588.1±23.0 °C(Predicted)
PSA：27.18000
LogP:7.05860
XLogP3:8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:8
Exact Mass:480.21357508
Heavy Atom Count:34
Complexity:465

Purity/Quality:

99% ^*data from raw suppliers

(1S,2S)-(+)-1,2-BIS(DIPHENYLPHOSPHINOMETHYL)CYCLOHEXANE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C(C1)CP(C2=CC=CC=C2)C3=CC=CC=C3)CP(C4=CC=CC=C4)C5=CC=CC=C5
Isomeric SMILES:C1CC[C@@H]([C@H](C1)CP(C2=CC=CC=C2)C3=CC=CC=C3)CP(C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of (1S,2S)-(+)-1,2-Bis(diphenylphosphinomethyl)cyclohexane

There total 3 articles about (1S,2S)-(+)-1,2-Bis(diphenylphosphinomethyl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 70223-77-7
(1S,2S)-1,2-bis(diphenylphosphinomethyl)cyclohexane

Guidance literature:: With sodium hydrogencarbonate; tetrafluoroboric acid dimethyl ether complex; In dichloromethane; 1.) a.) -5 up to 25 deg C; b.) 25 deg C, 12h; 2.) 0 deg C;
DOI:10.1016/0040-4020(95)00390-T

Reference yield:

: 610-10-6,1687-30-5,2305-32-0,21963-41-7,46022-05-3,610-09-3
(1S,2S)-cyclohexane-1,2-dicarboxylic acid

: 70223-77-7
(1S,2S)-1,2-bis(diphenylphosphinomethyl)cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 60 °C / Inert atmosphere

2.1: phosphorus tribromide / diethyl ether / Inert atmosphere

2.2: 255 / 90 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; phosphorus tribromide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1246/bcsj.20210023