1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one

Base Information

Chemical Name:1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one
CAS No.:58721-74-7
Molecular Formula:C₁₇H₁₉F₃N₂O
Molecular Weight:324.346
Hs Code.:
European Community (EC) Number:261-404-2
DSSTox Substance ID:DTXSID20886282
Nikkaji Number:J297.008B
Mol file:58721-74-7.mol

Synonyms:1,2,3,8-tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo(3,2-g)quinolin-7-one;LD-473

Suppliers and Price of 1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2,3,3,8-Pentamethyl-5-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[3,2-g]quinolin-7(8H)-one
5mg
$ 60.00

TCI Chemical
1,2,3,3,8-Pentamethyl-5-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[3,2-g]quinolin-7(8H)-one >98.0%(HPLC)(T)
200mg
$ 130.00

American Custom Chemicals Corporation
1,2,3,8-TETRAHYDRO-1,2,3,3,8-PENTAMETHYL-5-(TRIFLUOROMETHYL)-7H-PYRROLO[3,2-G]QUINOLIN-7-ONE 95.00%
5MG
$ 503.36

AK Scientific
1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one
200mg
$ 224.00

Total 8 raw suppliers

Chemical Property of 1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one

Chemical Property:

Vapor Pressure:9.26E-06mmHg at 25°C
Boiling Point:373°C at 760 mmHg
PKA:5.93±0.70(Predicted)
Flash Point:179.4°C
Density:1.216g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:324.14494772
Heavy Atom Count:23
Complexity:555

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,3,8-Pentamethyl-5-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[3,2-g]quinolin-7(8H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C(C2=C(N1C)C=C3C(=C2)C(=CC(=O)N3C)C(F)(F)F)(C)C

Technology Process of 1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one

There total 5 articles about 1,2,3,8-Tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1640-39-7
2,3,3-trimethylindoleniune

: 58721-74-7
LD473

Guidance literature:: Multi-step reaction with 6 steps

1: Na(CN)BH₃, AcOH / Ambient temperature

2: aq. 70percent HNO₃, H₂SO₄ / 0.08 h / 0 °C

3: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr

4: ZnCl₂ / ethanol / 16 h / Heating

5: Na(CN)BH₃, AcOH / Ambient temperature

6: NaH / dimethylformamide / 0 °C

With sulfuric acid; hydrogen; nitric acid; sodium hydride; sodium cyanoborohydride; acetic acid; zinc(II) chloride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00107-3

Reference yield:

: 6-nitro-2,3-dihydro-2,3,3-trimethyl-1H-indole

: 58721-74-7
LD473

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr

2: ZnCl₂ / ethanol / 16 h / Heating

3: Na(CN)BH₃, AcOH / Ambient temperature

4: NaH / dimethylformamide / 0 °C

With hydrogen; sodium hydride; sodium cyanoborohydride; acetic acid; zinc(II) chloride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00107-3

Reference yield:

: 18781-58-3,130760-87-1,130760-88-2
2,3,3-trimethyl-2,3-dihydro-1H-indole

: 58721-74-7
LD473

Guidance literature:: Multi-step reaction with 5 steps

1: aq. 70percent HNO₃, H₂SO₄ / 0.08 h / 0 °C

2: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr

3: ZnCl₂ / ethanol / 16 h / Heating

4: Na(CN)BH₃, AcOH / Ambient temperature

5: NaH / dimethylformamide / 0 °C

With sulfuric acid; hydrogen; nitric acid; sodium hydride; sodium cyanoborohydride; acetic acid; zinc(II) chloride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00107-3