homodestruxin B

Base Information

Chemical Name:homodestruxin B
CAS No.:110538-19-7
Molecular Formula:C31H53 N5 O7
Molecular Weight:607.791
Hs Code.:

Synonyms:Pyrrolo[1,2-d][1,4,7,10,13,16]oxapentaazacyclononadecine,cyclic peptide deriv.; Cyclo[N-methyl-L-alanyl-b-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-isoleucyl]

Suppliers and Price of homodestruxin B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of homodestruxin B

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:879.635°C at 760 mmHg
Flash Point:485.786°C
PSA：145.43000
Density:1.162g/cm³
LogP:2.17740

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of homodestruxin B

There total 10 articles about homodestruxin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 383397-11-3
Boc-βAla-Hmp-Pro-Ile-MeIle-MeAlaNHNHBoc

: 110538-19-7
homodestruxin B

Guidance literature:: Boc-βAla-Hmp-Pro-Ile-MeIle-MeAlaNHNHBoc; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With hydrogenchloride; sodium nitrite; for 0.25h;

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 15h; Further stages.;
DOI:10.1021/jo015953+

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 110538-19-7
homodestruxin B

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / DCC; HOBt hydrate / CH₂Cl₂ / 21 h / 0 - 20 °C

2.1: 98 percent / DCC; DMAP / CH₂Cl₂ / 21 h / 0 - 20 °C

3.1: H₂ / Pd/C / methanol / 2 h

4.1: 92 percent / PyBrop; i-Pr₂EtN / CH₂Cl₂ / 0 - 20 °C

5.1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

5.2: NaNO₂; aq. HCl / 0.25 h

5.3: 58 percent / aq. NaHCO₃ / CH₂Cl₂ / 15 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo015953+

Reference yield:

: 187753-73-7
(S)-1-((R)-2-Hydroxy-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzyl ester

: 110538-19-7
homodestruxin B

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / DCC; DMAP / CH₂Cl₂ / 21 h / 0 - 20 °C

2.1: H₂ / Pd/C / methanol / 2 h

3.1: 92 percent / PyBrop; i-Pr₂EtN / CH₂Cl₂ / 0 - 20 °C

4.1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

4.2: NaNO₂; aq. HCl / 0.25 h

4.3: 58 percent / aq. NaHCO₃ / CH₂Cl₂ / 15 h / 20 °C

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo015953+