(6-amino-2-oxo-1,2-dihydropyrimidin-5-yl)methanesulfonic acid

Base Information

• Chemical Name: (6-amino-2-oxo-1,2-dihydropyrimidin-5-yl)methanesulfonic acid
• CAS No.: 62374-22-5
• Molecular Formula: C₅H₇N₃O₄S
• Molecular Weight: 205.194
• Mol file: 62374-22-5.mol

Synonyms:5-Pyrimidinemethanesulfonicacid, 4-amino-1,2-dihydro-2-oxo- (9CI); NSC 278890

Chemical Property of (6-amino-2-oxo-1,2-dihydropyrimidin-5-yl)methanesulfonic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.94g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-amino-2-oxo-1,2-dihydropyrimidin-5-yl)methanesulfonic acid

There total 4 articles about (6-amino-2-oxo-1,2-dihydropyrimidin-5-yl)methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxymethylcytosine (1123-95-1) → cytosine 5-methylenesulfonate (62374-22-5)

Guidance literature:

With sodium hydrogensulfite;

DOI:10.1038/nature10102

Reference yield:

5-hydroxymethylcytosine (1123-95-1) + sodium 1-thio-β-D-glucopyranoside (10593-29-0) → 5-(1-β-D-glucopyranosyl)thiomethylcytosine (1433286-48-6) + cytosine 5-methylenesulfonate (62374-22-5)

Guidance literature:

With sodium metabisulfite; sodium phosphate; In water; at 42 ℃; for 24h; pH=5;

DOI:10.1002/anie.201300413

Reference yield:

5-hydroxymethylcytosine (1123-95-1) + glutathion (70-18-8) → S-(5-methylenecytosinyl)glutathione + cytosine 5-methylenesulfonate (62374-22-5)

Guidance literature:

With sodium metabisulfite; sodium phosphate; In water; at 42 ℃; for 24h; pH=5; Time; Concentration; Solvent; Kinetics;

DOI:10.1002/anie.201300413

upstream raw materials:

5-hydroxymethylcytosine

sodium 1-thio-β-D-glucopyranoside

glutathion