Doxazosin, (R)-

Base Information

Chemical Name:Doxazosin, (R)-
CAS No.:70918-17-1
Molecular Formula:C23H25N5O5
Molecular Weight:451.48
Hs Code.:
UNII:F6HQ441M9W
Nikkaji Number:J3.544.770I
Wikidata:Q27167084
ChEMBL ID:CHEMBL1363589
Mol file:70918-17-1.mol

Synonyms:Doxazosin, (R)-;70918-17-1;R-Doxazosin;F6HQ441M9W;[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone;(4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)((2R)-2,3-dihydro-1,4-benzodioxin-2-yl)methanone;(R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone;Methanone, (4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)((2R)-2,3-dihydro-1,4-benzodioxin-2-yl)-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(((2R)-2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, (R)-;(-)-(R)-Doxazosin;UNII-F6HQ441M9W;SCHEMBL97513;MLS001165720;CHEMBL1363589;CHEBI:95247;HMS2233L12;NCGC00018158-01;NCGC00018158-04;PD132712;SMR000550476;J3.544.770I;EN300-19631171;Q27167084;[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone;2-{4-[(2R)-2,3-dihydro-1,4-benzodioxine-2-carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine

Suppliers and Price of Doxazosin, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Doxazosin
100mg
$ 1470.00

American Custom Chemicals Corporation
R-DOXAZOSIN 95.00%
5MG
$ 499.11

Total 9 raw suppliers

Chemical Property of Doxazosin, (R)-

Chemical Property:

Boiling Point:718.0±70.0 °C(Predicted)
PKA:6.52±0.50(Predicted)
PSA：112.27000
Density:1.371±0.06 g/cm3(Predicted)
LogP:2.30190
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:451.18556891
Heavy Atom Count:33
Complexity:678

Purity/Quality:

99% ^*data from raw suppliers

(R)-Doxazosin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
Isomeric SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)[C@H]4COC5=CC=CC=C5O4)N)OC
Uses (R)-Doxazosin is an Isomer of Doxazosin Mesylate (D537500) a selective α1-adrenoceptor antagonist. Doxazosin relaxes smooth muscles of the prostate.

Technology Process of Doxazosin, (R)-

There total 40 articles about Doxazosin, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%