1-BENZYL-2,2-DIFLUORO-ETHYLAMINE

Base Information

• Chemical Name: 1-BENZYL-2,2-DIFLUORO-ETHYLAMINE
• CAS No.: 71025-65-5
• Molecular Formula: C9H11F2N
• Molecular Weight: 171.1871464
• Hs Code.: 2921499090
• Mol file: 71025-65-5.mol

Synonyms:1-BENZYL-2,2-DIFLUORO-ETHYLAMINE

Chemical Property of 1-BENZYL-2,2-DIFLUORO-ETHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0324mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 243.3°C at 760 mmHg
• Flash Point: 122.9°C
• PSA: 26.02000
• Density: 1.111g/cm³
• LogP: 2.52180

Purity/Quality:

99% ^*data from raw suppliers

1-BENZYL-2,2-DIFLUORO-ETHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-2,2-DIFLUORO-ETHYLAMINE

There total 2 articles about 1-BENZYL-2,2-DIFLUORO-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

difluoroacetonitrile (359-12-6) + benzylmagnesium chloride (6921-34-2) → 1,1-difluoro-3-phenyl-2-aminopropane (71025-65-5)

Guidance literature:

difluoroacetonitrile; benzylmagnesium chloride; In diethyl ether; at -40 - -20 ℃; for 2h;

With sodium tetrahydroborate; In methanol; diethyl ether; water; at -20 - 0 ℃; for 2h;

DOI:10.1021/jm051262k

Reference yield:

→ 1,1-difluoro-3-phenyl-2-aminopropane (71025-65-5)

Guidance literature:

Carbonsaeure 4a, SOCl2, NaN3, W., Acn., H⁺, Bzl.;

DOI:10.1016/S0040-4039(01)85856-1

Reference yield:

1,1-difluoro-3-phenyl-2-aminopropane (71025-65-5) + methyl chloroformate (79-22-1) → (+/-)-methyl N-(1-difluoro-3-phenyl-prop-2-yl)carbamate (889861-37-4)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm051262k

upstream raw materials:

difluoroacetonitrile

benzylmagnesium chloride

Downstream raw materials:

(+/-)-methyl N-(1-difluoro-3-phenyl-prop-2-yl)carbamate

(+/-)-7-(N-4-chlorophenylaminosulfonyl)-3-difluoromethyl-3,4-dihydroisoquinolin-1-(2H)-one

(+/-)-3-difluoromethyl-7-(N-4-nitrophenylaminosulfonyl)-3,4-dihydroisoquinolin-1-(2H)-one

Refernces