N-(2-fluorobenzyl)ethanamine

Base Information

• Chemical Name: N-(2-fluorobenzyl)ethanamine
• CAS No.: 64567-25-5
• Molecular Formula: C9H12 F N
• Molecular Weight: 153.199
• Hs Code.: 2921499090
• European Community (EC) Number: 846-548-1
• Mol file: 64567-25-5.mol

Synonyms:N-(2-fluorobenzyl)ethanamine;64567-25-5;ETHYL[(2-FLUOROPHENYL)METHYL]AMINE;N-Ethyl-2-fluorobenzylamine;N-[(2-fluorophenyl)methyl]ethanamine;n-ethyl-o-fluorobenzylamine;ethyl-(2-fluoro-benzyl)-amine;SCHEMBL631227;N-(2-Fluorobenzyl) ethanamine;AEWPBFIYUCYSHZ-UHFFFAOYSA-N;N-(2-Fluorobenzyl)ethanamine x1hcl;MFCD00053427;STK513266;AKOS000160931;SB76078;CS-0246272;EN300-32131;F2169-1237;Z286282968

Chemical Property of N-(2-fluorobenzyl)ethanamine

Chemical Property:

• Vapor Pressure: 0.471mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 193.2°C at 760 mmHg
• Flash Point: 70.6°C
• PSA: 12.03000
• Density: 1.009g/cm³
• LogP: 2.32610
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 153.095377549
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Fluorobenzyl)ethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC1=CC=CC=C1F
• Uses: N-(2-Fluorobenzyl)ethanamine is used in preparation of heterocycles as angiotensin AT-2 receptor antagonists.

Technology Process of N-(2-fluorobenzyl)ethanamine

There total 2 articles about N-(2-fluorobenzyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-ethyl 2-fluorobenzamide (150079-54-2) → ethyl-(2-fluoro-benzyl)-amine (64567-25-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.39.3225

Reference yield:

N-(2-fluorobenzyl)acetamide (86010-67-5) → ethyl-(2-fluoro-benzyl)-amine (64567-25-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃;

DOI:10.1016/j.bmcl.2008.03.026

Reference yield: 88.0%

{4-[(2S)-2,3-diethoxy-3-oxopropyl]phenoxy}acetic acid (549501-68-0) + ethyl-(2-fluoro-benzyl)-amine (64567-25-5) → ethyl (2S)-2-ethoxy-3-(4-{2-[ethyl(2-fluorobenzyl)amino]-2-oxoethoxy}phenyl)propanoate

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃;

upstream raw materials:

N-ethyl 2-fluorobenzamide

N-(2-fluorobenzyl)acetamide

Downstream raw materials:

N-ethyl-N-(2-fluorobenzyl)-2-(4-hydroxyphenoxy)acetamide

N-ethyl-N-(2-fluorobenzyl)-2-(4-hydroxyphenyl)acetamide

N-ethyl-N-(2-fluorobenzyl)-3-(4-hydroxyphenyl)propanamide