Technology Process of 3β-Vinyl-1,2,3,4,6,7,12,12bβ-octahydroindolo[2,3-a]quinolizine-2α-ethanol
There total 12 articles about 3β-Vinyl-1,2,3,4,6,7,12,12bβ-octahydroindolo[2,3-a]quinolizine-2α-ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.201102012
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1,4-dioxane / 1 h / 90 °C
2: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine / dichloromethane / 20 °C
3: acetyl chloride / dichloromethane / 20 °C
4: 2,6-di-tert-butyl-pyridine / dichloromethane / 20 °C
5: sodium tetrahydroborate / methanol / 1 h / 0 °C
6: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C
7: pyridine; dmap / dichloromethane / 0 - 20 °C
8: acetic acid / methanol / 20 °C
9: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; 2,6-di-tert-butyl-pyridine; (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; water; acetic acid; acetyl chloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1002/chem.201102012
- Guidance literature:
-
Multi-step reaction with 7 steps
1: acetyl chloride / dichloromethane / 20 °C
2: 2,6-di-tert-butyl-pyridine / dichloromethane / 20 °C
3: sodium tetrahydroborate / methanol / 1 h / 0 °C
4: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C
5: pyridine; dmap / dichloromethane / 0 - 20 °C
6: acetic acid / methanol / 20 °C
7: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; 2,6-di-tert-butyl-pyridine; water; acetic acid; acetyl chloride;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1002/chem.201102012
