diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate

Base Information

• Chemical Name: diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate
• CAS No.: 65939-65-3
• Molecular Formula: C22H21 N O4
• Molecular Weight: 363.4064
• Mol file: 65939-65-3.mol

Synonyms:2H-Pyrrole-2,2-dicarboxylicacid, 3,5-diphenyl-, diethyl ester (9CI); NSC 321214

Chemical Property of diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate

Chemical Property:

• Vapor Pressure: 1.83E-08mmHg at 25°C
• Boiling Point: 455°C at 760 mmHg
• Flash Point: 165.6°C
• Density: 1.14g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate

There total 7 articles about diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(±)-diethyl 3,5-diphenyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate (65939-64-2) → 3,5-diphenyl 2H pyrrole-2,2-dicarboxylate de diethyle (65939-65-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 25 ℃; for 5h;

Reference yield: 46.0%

2-((Z)-3-Oxo-1,3-diphenyl-propenylamino)-malonic acid diethyl ester (100784-99-4) → 3,5-diphenyl 2H pyrrole-2,2-dicarboxylate de diethyle (65939-65-3)

Guidance literature:

With ethyl phosphate; In chloroform; for 17h; Heating;

Reference yield:

diethyl aminomalonate hydrochloride (13433-00-6) → 3,5-diphenyl 2H pyrrole-2,2-dicarboxylate de diethyle (65939-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / anhydrous K₂CO₃ / 30 h / 170 - 190 °C

2: 63 percent / DDQ / benzene / 5 h / 25 °C

With potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene;

upstream raw materials:

(±)-diethyl 3,5-diphenyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate

2-((Z)-3-Oxo-1,3-diphenyl-propenylamino)-malonic acid diethyl ester

aminomalonic acid diethyl ester

diethyl aminomalonate hydrochloride

Downstream raw materials:

3,5-diphenyl pyrrole-1,2-dicarboxylate de diethyle

3,5-diphenyl-1H-pyrrole-2-carboxylic acid ethyl ester