5-FLUORO-2-THIOPHENECARBOXYLIC ACID

Base Information

• Chemical Name: 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
• CAS No.: 4377-58-6
• Molecular Formula: C5H3FO2S
• Molecular Weight: 146.142
• Hs Code.: 2934999090
• Mol file: 4377-58-6.mol

Synonyms:5-Carboxy-2-fluorothiophene;5-Fluorothiophen-2-carboxylic acid;5-Fluorothiophene-2-carboxylic acid;

Chemical Property of 5-FLUORO-2-THIOPHENECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 139-141℃
• Refractive Index: 1.574
• Boiling Point: 271.178 °C at 760 mmHg
• PKA: 3.52±0.10(Predicted)
• Flash Point: 117.804 °C
• PSA: 65.54000
• Density: 1.528 g/cm³
• LogP: 1.58540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluorothiophene-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-2-THIOPHENECARBOXYLIC ACID

There total 4 articles about 5-FLUORO-2-THIOPHENECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-5-(2-Benzyloxy-4,5-dimethoxy-phenyl)-hex-2-enoic acid ethyl ester → 5-fluorothiophene-2-carboxylic acid (4377-58-6)

Guidance literature:

With sodium hydroxide; In water; for 3h; Heating;

DOI:10.1080/00397910008087280

Reference yield:

5-fluorothiophene-2-carbonitrile (32415-91-1) → 5-fluorothiophene-2-carboxylic acid (4377-58-6)

Guidance literature:

With sodium hydroxide;

Reference yield:

5-nitro-2-thienyl cyanide (16689-02-4) → 5-fluorothiophene-2-carboxylic acid (4377-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride; tetraphenylphosphonium bromide; Phthaloyl dichloride / sulfolane / 2 h / 180 °C

2: sodium hydroxide; water / 2 h / 100 °C

With potassium fluoride; water; tetraphenylphosphonium bromide; Phthaloyl dichloride; sodium hydroxide; In sulfolane;

upstream raw materials:

5-fluorothiophene-2-carbonitrile

5-nitro-2-thienyl cyanide

Downstream raw materials:

(5-fluorothiophen-2-yl)formyl chloride

5-fluorothiophene-2-carbaldehyde

N-[(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-6-(prop-2-en-1-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide

N-[(4aR,7aR)-6-(5-fluoropyrimidin-2-yl)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide

Refernces

• 1、 Chambers,Marfat. "An improved synthesis of 5-fluorothiophene-2-carboxylic acid". . p. 3629 - 3632. Retrieved 2007/10/03.
• 2、 -. "Processes and intermediates for preparing 2-fluorothiophene derivatives". . . Retrieved 2008/06/13.