(R)-quinuclidin-3-amine hydrochloride

Base Information

• Chemical Name: (R)-quinuclidin-3-amine hydrochloride
• CAS No.: 137661-31-5
• Molecular Formula: C7H14 N2 . Cl H
• Molecular Weight: 162.662
• Mol file: 137661-31-5.mol

Synonyms:1-Azabicyclo[2.2.2]octan-3-amine,monohydrochloride, (3R)- (9CI);1-Azabicyclo[2.2.2]octan-3-amine, monohydrochloride,(R)-; (R)-(1-Azabicyclo[2.2.2]oct-3-yl)amine monohydrochloride

Chemical Property of (R)-quinuclidin-3-amine hydrochloride

Chemical Property:

• PSA: 29.26000
• LogP: 1.47950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-Quinuclidin-3-AmineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-quinuclidin-3-amine hydrochloride

There total 21 articles about (R)-quinuclidin-3-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3S)-3-<(R)-(1-phenyl)ethylamino>-quinuclidine dihydrochloride (120570-09-4,124808-82-8,128311-06-8) → (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In propan-1-ol; water; at 40 ℃;

DOI:10.1080/00397919608003556

Reference yield: 70.0%

(3R)-3-<(S)-(1-phenyl)ethylamino>-quinuclidine dihydrochloride (120570-09-4,124808-82-8,128311-06-8) → (3R)-quinuclidin-3-amine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; water; at 50 ℃; for 4h; under 760 Torr;

DOI:10.1080/00397919208021320

Reference yield: 25.0%

N-<(3S)-3-quinuclidinyl> phthalimide (142999-65-3) → (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1080/00397919208021320

upstream raw materials:

N-<(3S)-3-quinuclidinyl> phthalimide

(3S)-3-<(R)-(1-phenyl)ethylamino>-quinuclidine dihydrochloride

(3S)-3-<(R)-(1-phenyl)ethylamino>-quinuclidine

3-Quinuclidinone

Downstream raw materials:

(S)-(-)-(1-Aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid benzyl ester