7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine

Base Information

• Chemical Name: 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine
• CAS No.: 923282-39-7
• Molecular Formula: C6H5ClN4
• Molecular Weight: 168.585
• Hs Code.: 2933990090
• Mol file: 923282-39-7.mol

Synonyms:7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine;1H-pyrazolo[4,3-d]pyrimidine, 7-chloro-1-methyl-;

Chemical Property of 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine

Chemical Property:

• Vapor Pressure: 0.00282mmHg at 25°C
• Refractive Index: 1.743
• Boiling Point: 294.6 °C at 760 mmHg
• Flash Point: 132 °C
• PSA: 43.60000
• Density: 1.59 g/cm³
• LogP: 1.01670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine

There total 2 articles about 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol (314021-93-7) → 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine (923282-39-7)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 90 ℃; for 1h;

Reference yield:

4-amino-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (1260659-38-8) → 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine (923282-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 h / 180 °C

2: trichlorophosphate / 16 h / 120 °C

With trichlorophosphate;

Reference yield: 80.0%

7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine (923282-39-7) + (1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride (412356-24-2,1683576-26-2) → 1-methyl-N-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine

Guidance literature:

With sodium carbonate; In acetonitrile; at 80 ℃;

upstream raw materials:

1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol

4-amino-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

Downstream raw materials:

N-[2-[3-methoxy-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl] ethyl]-1-methylpyrazolo[4,3-d]pyrimidin-7-amine

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