Imidazo[1,2-a]pyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-
• CAS No.: 917364-11-5
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Hs Code.: 2933990090
• Mol file: 917364-11-5.mol

Synonyms:5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid;

Chemical Property of Imidazo[1,2-a]pyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-

Chemical Property:

• Boiling Point: 449.8 °C at 760 mmHg
• PKA: 1.68±0.20(Predicted)
• Flash Point: 225.8 °C
• PSA: 55.12000
• Density: 1.45 g/cm³
• LogP: 0.91760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5,6,7,8-Tetrahydroimidazo[1,2-A]pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-

There total 1 articles about Imidazo[1,2-a]pyridine-2-carboxylic acid, 5,6,7,8-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

imidazo[1,2-a]pyridine-2-carboxylic acid (64951-08-2) → 5,6,7,8-tetrahydroimidazo [1,2-a]pyridine-2-carboxylic acid (917364-11-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; under 3000.3 Torr;

Reference yield:

5,6,7,8-tetrahydroimidazo [1,2-a]pyridine-2-carboxylic acid (917364-11-5) + tert-butyl 4-(3-(3'-(3-((1s,4s)-4-aminocyclohexylcarbamoyl)-5-fluoropyridin-2-yloxy)biphenyl-4-yl)propyl)piperazine-1-carboxylate → N-((1s,4s)-4-(5-fluoro-2-(4'-(3-(piperazin-1-yl)propyl)biphenyl-3-yloxy)nicotinamido)cyclohexyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; acetonitrile / 1 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

imidazo[1,2-a]pyridine-2-carboxylic acid

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