5-Chloro-4,6-dihydroxynicotinic acid ethyl ester

Base Information

Chemical Name:5-Chloro-4,6-dihydroxynicotinic acid ethyl ester
CAS No.:846541-71-7
Molecular Formula:C₈H₈ClNO₄
Molecular Weight:217.609
Hs Code.:2933399090
Mol file:846541-71-7.mol

Synonyms:Nicotinicacid, 5-chloro-4,6-dihydroxy-, ethyl ester (5CI);5-Chloro-4,6-dihydroxynicotinicacid ethyl ester;Ethyl 5-chloro-6-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxylate;5-Chloro-4,6-dihydroxypyridine-3-carboxylic acid ethyl ester;Ethyl 5-chloro-4,6-dihydroxypyridine-3-carboxylate;

Suppliers and Price of 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl5-chloro-4,6-dihydroxynicotinate 95+%
1g
$ 551.00

Chemenu
Ethyl5-chloro-4,6-dihydroxynicotinate 95%
1g
$ 520.00

American Custom Chemicals Corporation
5-CHLORO-4,6-DIHYDROXYPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
5G
$ 909.56

Alichem
Ethyl5-chloro-4,6-dihydroxynicotinate
1g
$ 614.25

Alichem
Ethyl5-chloro-4,6-dihydroxynicotinate
250mg
$ 243.36

Total 20 raw suppliers

Chemical Property of 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester

Chemical Property:

Vapor Pressure:2.05E-05mmHg at 25°C
Refractive Index:1.573
Boiling Point:323.5 °C at 760 mmHg
Flash Point:149.4 °C
PSA：79.65000
Density:1.49 g/cm³
LogP:1.32290
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl5-chloro-4,6-dihydroxynicotinate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester

There total 1 articles about 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6975-44-6
4,6-dihydroxynicotinic acid ethyl ester

: 846541-71-7
ethyl 5-chloro-4,6-dihydroxynicotinate

Guidance literature:: With hydrogenchloride; dihydrogen peroxide;

Reference yield:

: 846541-71-7
ethyl 5-chloro-4,6-dihydroxynicotinate

: 847373-09-5
methyl 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 6.04 g / POCl₃; TEA / 4 h / 60 °C

2.1: aq. NaOH / tetrahydrofuran; methanol / 0.5 h / 20 °C

3.1: LiHMDS / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 8.64 g / tetrahydrofuran; hexane / -78 - 20 °C

4.1: 91 percent / ethanol; hexane

With sodium hydroxide; TEA; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane;
DOI:10.1021/jm050834y

Reference yield:

: 846541-71-7
ethyl 5-chloro-4,6-dihydroxynicotinate

: 874353-11-4
methyl 4-(4-bromo-2-chlorophenylamino)-5-chloro-6-methoxynicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 6.04 g / POCl₃; TEA / 4 h / 60 °C

2.1: aq. NaOH / tetrahydrofuran; methanol / 0.5 h / 20 °C

3.1: LiHMDS / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 8.64 g / tetrahydrofuran; hexane / -78 - 20 °C

4.1: 91 percent / ethanol; hexane

5.1: 49 percent / NaH / tetrahydrofuran / 16 h / 20 °C

With sodium hydroxide; TEA; sodium hydride; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane;
DOI:10.1021/jm050834y