(3beta,4alpha)-3,4-dihydroxygona-1,5(10),6,8,11,13-hexaen-17-one

Base Information

Chemical Name:(3beta,4alpha)-3,4-dihydroxygona-1,5(10),6,8,11,13-hexaen-17-one
CAS No.:143290-36-2
Molecular Formula:C₁₇H₁₄O₃
Molecular Weight:266.296
Hs Code.:

Synonyms:17H-Cyclopenta[a]phenanthren-17-one,3,4,15,16-tetrahydro-3,4-dihydroxy-, trans- (9CI); 17H-Cyclopenta[a]phenanthren-17-one,3,4,15,16-tetrahydro-3,4-dihydroxy-, trans-(?à)-

Suppliers and Price of (3beta,4alpha)-3,4-dihydroxygona-1,5(10),6,8,11,13-hexaen-17-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3beta,4alpha)-3,4-dihydroxygona-1,5(10),6,8,11,13-hexaen-17-one

Chemical Property:

Vapor Pressure:2E-12mmHg at 25°C
Boiling Point:538.4°C at 760 mmHg
Flash Point:293.5°C
Density:1.453g/cm³

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3beta,4alpha)-3,4-dihydroxygona-1,5(10),6,8,11,13-hexaen-17-one

There total 20 articles about (3beta,4alpha)-3,4-dihydroxygona-1,5(10),6,8,11,13-hexaen-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: Acetic acid (3S,4S)-3-acetoxy-17-oxo-4,15,16,17-tetrahydro-3H-cyclopenta[a]phenanthren-4-yl ester

: 143290-36-2,148021-80-1
3,4,15,16-tetrahydro-trans-3,4-dihydroxycyclopenta phenanthren-17-one

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol; for 0.166667h; Heating;
DOI:10.1021/jo00054a018

Reference yield: 83.0%

: 143216-83-5
3,4,15,16-tetrahydro-trans-3,4-bis<(tert-butyldimethylsilyl)oxy>cyclopenta phenanthren-17-one

: 143290-36-2,148021-80-1
3,4,15,16-tetrahydro-trans-3,4-dihydroxycyclopenta phenanthren-17-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1.5h; Ambient temperature;
DOI:10.1021/jo00047a030

Reference yield:

: 17521-83-4
3-methoxy-6,7,16,17-tetrahydro-15H-cyclopenta -phenanthren-17-one

: 143290-36-2,148021-80-1
3,4,15,16-tetrahydro-trans-3,4-dihydroxycyclopenta phenanthren-17-one

Guidance literature:: Multi-step reaction with 8 steps

1: 71 percent / 10percent Pd/C / various solvent(s) / 4 h / Heating

2: 95 percent / BBr₃ / CH₂Cl₂ / Ambient temperature

3: 92 percent / pyridine / 18 h

4: 77 percent / (PhSeO)2O / tetrahydrofuran / 4 h / Heating

5: NaBH₄, O₂ / ethanol / 96 h

6: Et₃N / benzene / 4 h / Ambient temperature

7: 52 percent / TiCl₃*3THF, DIBAL-H / toluene / 18 h

8: 83 percent / Bu₄NF / tetrahydrofuran / 1.5 h / Ambient temperature

With pyridine; sodium tetrahydroborate; titanium trichloride tris(tetrahydrofuran); (PhSeO)2O; tetrabutyl ammonium fluoride; oxygen; boron tribromide; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; benzene;
DOI:10.1021/jo00047a030