2'-Ethoxyuridine

Base Information

• Chemical Name: 2'-Ethoxyuridine
• CAS No.: 61373-43-1
• Molecular Formula: C₁₁H₁₆N₂O₆
• Molecular Weight: 272.258
• Hs Code.: 2934999090
• Mol file: 61373-43-1.mol

Synonyms:

Chemical Property of 2'-Ethoxyuridine

Chemical Property:

• PSA: 113.78000
• LogP: -1.80770

Purity/Quality:

97% ^*data from raw suppliers

2'-ETHOXY URIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-Ethoxyuridine

There total 3 articles about 2'-Ethoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2’-O-ethyl-5’-O-(4,4’-dimethoxytrityl)-uridine → 2’-O-ethyl-uridine (61373-43-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/ejoc.202001348

Reference yield:

uridine (58-96-8) → 2’-O-ethyl-uridine (61373-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 4 h / 20 °C

2.1: potassium carbonate / tetrahydrofuran / 0.08 h / Inert atmosphere

2.2: 36 h / 50 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With pyridine; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.202001348

Reference yield:

→ 2’-O-ethyl-uridine (61373-43-1)

Guidance literature:

2'-O-Aethylcytidin (2), NaNO2, 25percentig. wss. CH3COOH;

upstream raw materials:

uridine

Refernces