3-Bromo-2-pyridinecarboxaldehyde

Base Information

• Chemical Name: 3-Bromo-2-pyridinecarboxaldehyde
• CAS No.: 405174-97-2
• Molecular Formula: C6H4BrNO
• Molecular Weight: 186.008
• Hs Code.: 2933399090
• Mol file: 405174-97-2.mol

Synonyms:3-Bromo-2-formylpyridine;

Chemical Property of 3-Bromo-2-pyridinecarboxaldehyde

Chemical Property:

• Vapor Pressure: 0.099mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 222.989 °C at 760 mmHg
• PKA: 1.12±0.10(Predicted)
• Flash Point: 88.661 °C
• PSA: 29.96000
• Density: 1.683 g/cm³
• LogP: 1.65660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromopyridine-2-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2-pyridinecarboxaldehyde

There total 6 articles about 3-Bromo-2-pyridinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-bromo-2-(dibromomethyl)pyridine → 3-bromopicolinaldehyde (405174-97-2)

Guidance literature:

With calcium carbonate; In water; for 8h; Heating;

DOI:10.1016/j.tetlet.2005.07.016

Reference yield: 84.0%

3-Bromopyridine (626-55-1,163928-56-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-bromopicolinaldehyde (405174-97-2)

Guidance literature:

3-Bromopyridine; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 0.0166667h;

N,N-dimethyl-formamide; In tetrahydrofuran; at 25 ℃; for 0.0308333h; Concentration;

DOI:10.1002/anie.201404221

Reference yield: 70.0%

3-bromo-2-picoline (38749-79-0) → 3-bromopicolinaldehyde (405174-97-2)

Guidance literature:

With selenium(IV) oxide; dimethyl sulfoxide;

DOI:10.1016/j.chempr.2019.10.003

upstream raw materials:

3-bromo-2-picoline

3-bromo-N-methoxy-N-methylpyridine-2-carboxamide

3-Bromopyridine

N,N-dimethyl-formamide

Downstream raw materials:

3-thiophen-2-yl-pyridine-2-carbaldehyde

2-[(3-bromopyridin-2-yl)(1H-indol-3-yl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone

Refernces

• 1、 Ippolito, Joseph A.,Niu, Haichan,Bertoletti, Nicole,Carter, Zachary J.,Jin, Shengyan,Spasov, Krasimir A.,Cisneros, José A.,Valhondo, Margarita,Cutrona, Kara J.,Anderson, Karen S.,Jorgensen, William L.. "Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead". supporting information. p. 249 - 255. Retrieved 2021/01/26.
• 2、 Minus, Matthew B.,Featherston, Aaron L.,Choi, Sooyun,King, Sam C.,Miller, Scott J.,Anslyn, Eric V.. "Reengineering a Reversible Covalent-Bonding Assembly to Optically Detect ee in β-Chiral Primary Alcohols". . p. 3196 - 3206. Retrieved 2019/12/11.