1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione
CAS No.:133070-83-4
Molecular Formula:C₁₈H₁₇N₃O₆
Molecular Weight:371.349
Hs Code.:
UNII:QF6L5ZD7AU
ChEMBL ID:CHEMBL2368958
DSSTox Substance ID:DTXSID60927921
Nikkaji Number:J412.607F
Wikidata:Q82902634

Synonyms:133070-83-4;1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione;QF6L5ZD7AU;CHEMBL2368958;DTXSID60927921;Uridine, 2'-deoxy-5-(3-phenyl-5-isoxazolyl)-;1-(2-Deoxypentofuranosyl)-4-hydroxy-5-(3-phenyl-1,2-oxazol-5-yl)pyrimidin-2(1H)-one;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(3-phenyl-1,2-oxazol-5-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(3-phenylisoxazol-5-yl)pyrimidine-2,4-dione

Suppliers and Price of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione

Chemical Property:

XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:371.11173527
Heavy Atom Count:27
Complexity:620

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=C(C(=O)NC2=O)C3=CC(=NO3)C4=CC=CC=C4)CO)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C3=CC(=NO3)C4=CC=CC=C4)CO)O

Technology Process of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione

There total 4 articles about 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-phenyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187734-33-3
C₂₂H₂₁N₃O₈

: 133070-83-4
5-(3-phenylisoxazol-5-yl)-2'-deoxyuridine

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃; for 10h;
DOI:10.1016/j.bmcl.2009.06.072

Reference yield:

: 133040-26-3
C₃₄H₂₉N₃O₈

: 133070-83-4
5-(3-phenylisoxazol-5-yl)-2'-deoxyuridine

Guidance literature:: With sodium methylate; In methanol; for 2h; Yield given;
DOI:10.1021/jm00110a003

Reference yield:

: 698-16-8
benzohydroximoyl chloride

: 133070-83-4
5-(3-phenylisoxazol-5-yl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 2 h / -20 - 20 °C

2: NaOCH₃ / methanol / 2 h

With sodium methylate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm00110a003