1-METHYLOCTAHYDROPYRROLO[3,4-B]PYRROLE

Base Information

• Chemical Name: 1-METHYLOCTAHYDROPYRROLO[3,4-B]PYRROLE
• CAS No.: 128740-09-0
• Molecular Formula: C7H14 N2
• Molecular Weight: 126.19900
• Hs Code.: 2933990090
• Mol file: 128740-09-0.mol

Synonyms:2-Methyl-2,7-diazabicyclo[3.3.0]octane;1-METHYLOCTAHYDROPYRROLO[3,4-B]PYRROLE;1-Methyl-hexahydropyrrolo[3,4-b]pyrrole;Pyrrolo[3,4-b]pyrrole,octahydro-1-methyl;1-methyl-octahydropyrrolo[2,3-c]pyrrole;

Chemical Property of 1-METHYLOCTAHYDROPYRROLO[3,4-B]PYRROLE

Chemical Property:

• Vapor Pressure: 2.264mmHg at 25°C
• Boiling Point: 161.52oC at 760 mmHg
• PKA: 11.04±0.20(Predicted)
• Flash Point: 55.536oC
• PSA: 15.27000
• Density: 0.97g/cm3
• LogP: 0.17660
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

1-Methyloctahydropyrrolo[3,4-b]pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYLOCTAHYDROPYRROLO[3,4-B]PYRROLE

There total 1 articles about 1-METHYLOCTAHYDROPYRROLO[3,4-B]PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (132414-83-6,1417789-32-2) → 2-Methyl-2,7-diazabicyclo[3.3.0]octane (128740-09-0)

Guidance literature:

With hydrogenchloride; potassium carbonate;

Reference yield: 79.0%

2-Methyl-2,7-diazabicyclo[3.3.0]octane (128740-09-0) + 6,7-difluoro-1-(4-hydroxyphenyl)-4-oxoquinoline-3-carboxylic acid (103995-00-2) → 6-fluoro-1-(4-hydroxy-phenyl)-7-(1-methyl-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 65 ℃; for 48h;

DOI:10.1021/jm0497895

Reference yield: 14.0%

7-[(2E)-4-bromobut-2-enoyl]-N-(3,4-dichlorophenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine (1130156-52-3) + 2-Methyl-2,7-diazabicyclo[3.3.0]octane (128740-09-0) → N-(3,4-dichlorophenyl)-7-[(2E)-4-(1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine (1130153-21-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 20h;

upstream raw materials:

ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

Downstream raw materials:

N-(3,4-dichlorophenyl)-7-[(2E)-4-(1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine

4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)pyrimidin-2-yl)amino)-N-(2-methyl-5-((1-methylhexahydropyrrole[3,4-b]pyrrolidin-5(1H)-yl)methyl)phenyl)benzamide

Refernces

• 1、 -. "Preparation of 2,7-diazabicyclo[3.3.0]octanes". . . Retrieved 2008/06/13.