NSC 23766 TETRAHYDROCHLORIDE

Base Information

Chemical Name:NSC 23766 TETRAHYDROCHLORIDE
CAS No.:733767-34-5
Molecular Formula:C₂₄H₃₅N₇
Molecular Weight:421.589
Hs Code.:
Mol file:733767-34-5.mol

Synonyms:NSC23766

Suppliers and Price of NSC 23766 TETRAHYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
NSC 23766 ≥99%(HPLC)
10
$ 166.00

Tocris
NSC 23766 ≥99%(HPLC)
50
$ 703.00

DC Chemicals
NSC-23766freebase >98%
1 g
$ 1900.00

DC Chemicals
NSC-23766freebase >98%
250 mg
$ 1000.00

American Custom Chemicals Corporation
NSC 23766 95.00%
5MG
$ 503.57

Alfa Aesar
NSC 23766
10mg
$ 129.00

Total 10 raw suppliers

Chemical Property of NSC 23766 TETRAHYDROCHLORIDE

Chemical Property:

Vapor Pressure:6.73E-16mmHg at 25°C
Boiling Point:632.4oC at 760 mmHg
Flash Point:336.2oC
PSA：91.99000
Density:1.16g/cm3
LogP:8.02300
Storage Temp.:Desiccate at RT
Sensitive.:Light Sensitive & Hygroscopic
Solubility.:Soluble in DMSO (50 mg/ml); Water (50 mg/ml)
Water Solubility.:Soluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

NSC 23766 ≥99%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
Uses The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.

Technology Process of NSC 23766 TETRAHYDROCHLORIDE

There total 1 articles about NSC 23766 TETRAHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: