(+)-stylopine

Base Information

• Chemical Name: (+)-stylopine
• CAS No.: 2884-83-5
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Mol file: 2884-83-5.mol

Synonyms:

Chemical Property of (+)-stylopine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-stylopine

There total 80 articles about (+)-stylopine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

14-bromo-6,7,12b,13-tetrahydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[4',5':7,8]isoquino[3,2-a]isoquinoline (65826-53-1) → Stylopine (84-39-9,2884-83-5,4312-32-7,7461-02-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; chloroform; at 20 ℃; for 24h;

Reference yield: 86.0%

(±)-8-oxostylopine (76177-42-9) → Stylopine (84-39-9,2884-83-5,4312-32-7,7461-02-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.75h; Heating;

DOI:10.1021/jo982451w

Reference yield: 85.0%

coptisine chloride (6020-18-4) → Stylopine (84-39-9,2884-83-5,4312-32-7,7461-02-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(02)00467-2

upstream raw materials:

rac-7-methyl-2,3;9,10-bis-methylenedioxy-berbinium; chloride

14-bromo-6,7,12b,13-tetrahydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[4',5':7,8]isoquino[3,2-a]isoquinoline

coptisine chloride

7,8-methylenedioxy-2-(3,4-methylenedioxyphenethyl)-1,2,3,4-tetrahydroisoquinolin-3-one

Downstream raw materials:

coptisine chloride

corydamine

protopine

Refernces

• 1、 Pandey,Ray,Dasgupta. "Quaternary alkaloids of Fumaria indica". . p. 545 - 546. Retrieved 1976.
• 2、 Lv, Jie,Li, Zhi-Hong,Deng, An-Jun,Qin, Hai-Lin. "A unified total synthesis of benzo[: D] [1,3]dioxole-type benzylisoquinoline alkaloids of aporphines, coptisines, and dibenzopyrrocolines". . p. 658 - 666. Retrieved 2022/01/28.
• 3、 -. "Berberine-based derivative and preparation method thereof, pharmaceutical composition, and antitumor uses of berberine-based derivative and pharmaceutical composition". Paragraph 0103. . Retrieved 2018/01/11.