C₄₁H₅₈N₂O₅

Base Information

• Chemical Name: C₄₁H₅₈N₂O₅
• CAS No.: 1584744-49-9
• Molecular Formula: C₄₁H₅₈N₂O₅
• Molecular Weight: 658.922
• Mol file: 1584744-49-9.mol

Synonyms:

Chemical Property of C₄₁H₅₈N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₅₈N₂O₅

There total 8 articles about C₄₁H₅₈N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + C27H41NO2 → C41H58N2O5 (1584744-49-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 19h; Inert atmosphere;

DOI:10.1021/ja501561c

Reference yield:

N-methyl-N-(4-methoxyphenyl)amine (5961-59-1) → C41H58N2O5 (1584744-49-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen bromide / water / 6 h / Reflux

2.1: sodium hydroxide / water; tetrahydrofuran / 0.17 h / 20 °C

2.2: 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere

With hydrogen bromide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja501561c

Reference yield:

N-methyl-p-aminophenol (150-75-4) → C41H58N2O5 (1584744-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 0.17 h / 20 °C

1.2: 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 70 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja501561c

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

N-methyl-N-(4-methoxyphenyl)amine

N-methyl-p-aminophenol

C₁₇H₂₅NO₅

Downstream raw materials:

C₄₉H₆₄N₂O₄

C₅₄H₇₂N₂O₆

C₇₁H₉₉N₅O₇

C₇₂H₁₀₂N₅O₇⁽¹⁺⁾*I^(1-)