2-methyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione

Base Information

Chemical Name:2-methyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione
CAS No.:5021-52-3
Molecular Formula:C₆H₅N₃O₂S
Molecular Weight:183.191
Hs Code.:

Synonyms:Thiazolo[5,4-d]pyrimidine-5,7-diol,2-methyl- (7CI,8CI); 2-Methyl-4H-thiazolo[5,4-d]pyrimidine-5,7-dione; NSC403368

Suppliers and Price of 2-methyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 2-methyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione

Chemical Property:

Density:1.522g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-methyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione

There total 12 articles about 2-methyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1093074-91-9
2-methyl-5-ureido-thiazole-4-carboxylic acid ethyl ester

: 5021-52-3
2-methyl-4H-thiazolo[5,4-d]pyrimidine-5,7-dione

Guidance literature:: With sodium hydroxide; In water; isopropyl alcohol; at 80 ℃; for 0.75h;

Reference yield: 80.0%

: 5-amino-6-sulfanylpyrimidine-2,4-diol

: 108-24-7
acetic anhydride

: 5021-52-3
2-Methyl-thiazolo<5,4-d>pyrimidin-5,7-diol

Guidance literature:: 5-amino-6-sulfanylpyrimidine-2,4-diol; acetic anhydride; at 140 ℃; for 1h;

With sodium hydroxide; In water; for 1h; Reflux;
DOI:10.1016/j.bmc.2018.05.048

Reference yield:

: 90877-70-6,4977-62-2
ethyl 2-acetamido-2-cyanoacetate

: 5021-52-3
2-methyl-4H-thiazolo[5,4-d]pyrimidine-5,7-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: Lawessons reagent / toluene / 18 h / Heating / reflux

2.1: dichloromethane / 0.75 h / 20 °C

2.2: 1 h / 90 °C

3.1: sodium hydroxide / water; isopropyl alcohol / 0.75 h / 80 °C

With Lawessons reagent; sodium hydroxide; In dichloromethane; water; isopropyl alcohol; toluene;