3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid

Base Information

Chemical Name:3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid
CAS No.:1364054-79-4
Molecular Formula:C₁₈H₁₈BrNO₅
Molecular Weight:408.249
Hs Code.:

Synonyms:

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Chemical Property of 3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid

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Technology Process of 3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid

There total 4 articles about 3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364054-53-4
dimethyl 4-[(4-bromobenzyl)oxy]pyridine-2,6-dicarboxylate

: 1364054-79-4
3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 17 h / 0 - 68 °C

2.1: selenium(IV) oxide / 1,4-dioxane / 20 h / 95 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.33 h / 0 °C

3.2: 19.5 h / 0 - 20 °C

4.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 60 °C / 760.05 Torr

5.1: potassium carbonate / acetonitrile / 17 h / 82 °C

6.1: water / 72 h / 100 °C

With selenium(IV) oxide; sodium tetrahydroborate; palladium on activated charcoal; water; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In 1,4-dioxane; methanol; acetonitrile; 3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination / 5.1: Williamson etherification;
DOI:10.1002/hlca.201100195

Reference yield:

: 1364054-57-8
{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dimethanol

: 1364054-79-4
3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: selenium(IV) oxide / 1,4-dioxane / 20 h / 95 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.33 h / 0 °C

2.2: 19.5 h / 0 - 20 °C

3.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 60 °C / 760.05 Torr

4.1: potassium carbonate / acetonitrile / 17 h / 82 °C

5.1: water / 72 h / 100 °C

With selenium(IV) oxide; palladium on activated charcoal; water; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In 1,4-dioxane; methanol; acetonitrile; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination / 4.1: Williamson etherification;
DOI:10.1002/hlca.201100195

Reference yield:

: 1364054-59-0
4-[(4-bromobenzyl)oxy]pyridine-2,6-dicarbaldehyde

: 1364054-79-4
3,3'-{4-[(4-bromobenzyl)oxy]pyridine-2,6-diyl}dipropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.33 h / 0 °C

1.2: 19.5 h / 0 - 20 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 60 °C / 760.05 Torr

3.1: potassium carbonate / acetonitrile / 17 h / 82 °C

4.1: water / 72 h / 100 °C

With palladium on activated charcoal; water; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In methanol; acetonitrile; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination / 3.1: Williamson etherification;
DOI:10.1002/hlca.201100195