11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)

Base Information

• Chemical Name: 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)
• CAS No.: 905-52-2
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.451
• Mol file: 905-52-2.mol

Synonyms:

Chemical Property of 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

11α,17α-Dihydroxy-1,4-pregnadiene-3,20-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 11α,17α-Dihydroxy-1,4-pregnadiene-3,20-dione is a steroid used in the preparation of Prednisolone (P703740), which functions as a synthetic corticosteroid.

Technology Process of 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)

There total 7 articles about 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H27BrO4 → 11β,17α-Dihydroxy-pregnadien-(1,4)-dion-(3,20) (905-52-2,20423-99-8,95118-55-1,111136-30-2)

Guidance literature:

With zinc; In diethyl ether; at 20 ℃; for 2.25h;

Reference yield:

17α-Hydroxy-pregna-1,4,9(11)-dien-3,20-dion (30934-01-1) → 11β,17α-Dihydroxy-pregnadien-(1,4)-dion-(3,20) (905-52-2,20423-99-8,95118-55-1,111136-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; N-Bromosuccinimide / acetone / 2.5 h / 0 - 10 °C

2: zinc / diethyl ether / 2.25 h / 20 °C

With N-Bromosuccinimide; acetic acid; zinc; In diethyl ether; acetone;

Reference yield:

→ 11β,17α-Dihydroxy-pregnadien-(1,4)-dion-(3,20) (905-52-2,20423-99-8,95118-55-1,111136-30-2)

Guidance literature:

17α-Hydroxy-pregna-1,4-dien-3,20-dion, Curvularia lunata-Kulturen, biochem. Oxidation;

upstream raw materials:

17α-Hydroxy-pregna-1,4,9(11)-dien-3,20-dion