Technology Process of 1-(trans-bromovinyl)-2,6,6-trimethylcyclohexene
There total 7 articles about 1-(trans-bromovinyl)-2,6,6-trimethylcyclohexene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodamide / 1.) ammonia liq., 1 h, 2.) ether, 2 h
2: copper sulphate trihydrate / xylene / 6 h / Heating
3: 1.) methyl-lithium / 1.) ether, -78 deg C, 1 h, 2.) -78 deg C, 2 h
4: 5 percent / di-isobutylaluminium hydride / tetrahydrofuran / 12 h / 55 - 60 °C
5: 1.) bromine, 2.) potassium fluoride / 1.) methylene dichloride, -78 deg C, 2.5 h, 2.) DMSO, room temperature, 4 h
With
potassium fluoride; diisobutylaluminum hydride; copper sulphate trihydrate; methyllithium; bromine; sodium amide;
In
tetrahydrofuran; xylene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) methyl-lithium / 1.) ether, -78 deg C, 1 h, 2.) -78 deg C, 2 h
2: 5 percent / di-isobutylaluminium hydride / tetrahydrofuran / 12 h / 55 - 60 °C
3: 1.) bromine, 2.) potassium fluoride / 1.) methylene dichloride, -78 deg C, 2.5 h, 2.) DMSO, room temperature, 4 h
With
potassium fluoride; diisobutylaluminum hydride; methyllithium; bromine;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 5 percent / di-isobutylaluminium hydride / tetrahydrofuran / 12 h / 55 - 60 °C
2: 1.) bromine, 2.) potassium fluoride / 1.) methylene dichloride, -78 deg C, 2.5 h, 2.) DMSO, room temperature, 4 h
With
potassium fluoride; diisobutylaluminum hydride; bromine;
In
tetrahydrofuran;
