methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

Base Information

Chemical Name:methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate
CAS No.:142929-52-0
Molecular Formula:C₂₇H₄₁N₃O₇S₂
Molecular Weight:583.77
Hs Code.:

methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

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Chemical Property of methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

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Technology Process of methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

There total 7 articles about methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-{2-[2-((S)-2-tert-Butoxycarbonylamino-3-methyl-3-tritylsulfanyl-butyrylamino)-ethoxy]-3-phenyl-propionylamino}-3-mercapto-3-methyl-butyric acid methyl ester

: 142929-52-0,143005-07-6
methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

Guidance literature:: With iodine; In acetic acid; for 0.333333h;
DOI:10.1021/jm00094a002

Reference yield:

: 29913-83-5
D-penicillamine methyl ester

: 142929-52-0,143005-07-6
methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

2: I₂ / aq. acetic acid / 0.33 h

With 4-methyl-morpholine; iodine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a002

Reference yield:

: 135592-14-2
N-Boc-S-trityl-D-Pen-OH

: 142929-52-0,143005-07-6
methyl 10α-<<(1,1-dimethylethoxy)carbonyl>amino>-6,6,9,9-tetramethyl-3,11-dioxo-2-(phenylmethyl)-1-oxa-7,8-dithia-4,12-diazacyclotetradecane-(5R)-5α-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1-methylmorpholine (NMM) / tetrahydrofuran / 0.75 h / -23 °C

2: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

3: aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C

4: 1-methylmorpholine (NMM) / tetrahydrofuran / 0.75 h / -23 °C

5: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

6: I₂ / aq. acetic acid / 0.33 h

With 4-methyl-morpholine; lithium hydroxide; iodine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a002