p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Base Information

Chemical Name:p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate
CAS No.:133076-32-1
Molecular Formula:C₆₂H₅₂N₈O₈S₄
Molecular Weight:1165.41
Hs Code.:

p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

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Chemical Property of p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

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Technology Process of p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

There total 9 articles about p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116240-90-5
p-methoxybenzyl 7-amino-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

: 133076-26-3
(Z)-2-(2-tritylaminothiazol-4-yl)-2-<2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino>acetic acid

: 133076-32-1,138514-59-7
p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: With trichlorophosphate; In dichloromethane; at -20 - -10 ℃;
DOI:10.1248/cpb.38.3476

Reference yield:

: 76-83-5
trityl chloride

: 133076-32-1,138514-59-7
p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

2: 1N NaOH / methanol

3: ethanol; CHCl₃ / Ambient temperature

4: POCl₃ / CH₂Cl₂ / -20 - -10 °C

With sodium hydroxide; trichlorophosphate; In methanol; ethanol; dichloromethane; chloroform;
DOI:10.1248/cpb.38.3476

Reference yield:

: 131580-89-7
3-Diphenylmethoxy-4-pyrone

: 133076-32-1,138514-59-7
p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 620 mg / methanol / 3 h / Ambient temperature

2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 5 °C

3: hydrazine monohydrate / CH₂Cl₂ / 5 °C

4: ethanol; CHCl₃ / Ambient temperature

5: POCl₃ / CH₂Cl₂ / -20 - -10 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform;
DOI:10.1248/cpb.38.3476