(3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one

Base Information

• Chemical Name: (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one
• CAS No.: 245039-91-2
• Molecular Formula: C₄₉H₇₈O₈Si₂
• Molecular Weight: 851.325

Synonyms:

Chemical Property of (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one

There total 9 articles about (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,4S)-6-Benzyloxy-4-methoxy-3-methyl-hexan-2-one (245039-82-1) + (2R,3R,4R,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-3-methoxymethoxy-2,4,6-trimethyl-heptanal (245039-87-6) → (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one (245039-91-2) + (3S,4R,7S,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(99)00868-0

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one (245039-91-2)

Guidance literature:

Multi-step reaction with 6 steps

1: lutidine

2: O₃; Me₂S / methanol

3: (R,R)-tartrate

4: i-Pr₂NEt / CH₂Cl₂

5: OsO₄; NMO; NaIO₄ / tetrahydrofuran; H₂O

6: LHMDS / tetrahydrofuran / -78 °C

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; dimethylsulfide; lutidine; d-tartrate ^(2-); ozone; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; 1: Etherification / 2: Oxidation / 3: Addition / 4: Etherification / 5: Oxidation / 6: Addition;

DOI:10.1016/S0040-4039(99)00868-0

Reference yield:

(3R,4R,5S)-6-(tert-butyldiphenylsiloxy)-4-hydroxy-3,5-dimethylhexan-1-ene (91751-27-8,91797-99-8,91798-00-4,91798-01-5,106357-24-8,106357-26-0,106357-27-1,106357-25-9) → (3S,4R,7R,8S,9S,10R,11S,12S)-1-[(benzyl)oxy]-11-[(tert-butyl-dimethylsilyl)oxy]-13-[(tert-butyl-diphenylsilyl)oxy]-7-hydroxy-3-methoxy-9-[(methoxymethyl)oxy]-4,8,10,12-tetramethyl-tridecan-5-one (245039-91-2)

Guidance literature:

Multi-step reaction with 6 steps

1: lutidine

2: O₃; Me₂S / methanol

3: (R,R)-tartrate

4: i-Pr₂NEt / CH₂Cl₂

5: OsO₄; NMO; NaIO₄ / tetrahydrofuran; H₂O

6: LHMDS / tetrahydrofuran / -78 °C

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; dimethylsulfide; lutidine; d-tartrate ^(2-); ozone; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; 1: Etherification / 2: Oxidation / 3: Addition / 4: Etherification / 5: Oxidation / 6: Addition;

DOI:10.1016/S0040-4039(99)00868-0

upstream raw materials:

(3R,4S)-6-Benzyloxy-4-methoxy-3-methyl-hexan-2-one

(2R,3R,4R,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-3-methoxymethoxy-2,4,6-trimethyl-heptanal

t-butyldimethylsiyl triflate

(3R,4R,5S)-6-(tert-butyldiphenylsiloxy)-4-hydroxy-3,5-dimethylhexan-1-ene

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