Technology Process of (+/-)-occidentalol
There total 13 articles about (+/-)-occidentalol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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73878-86-1
(4aS,8S,8aR)-4a,8-Dimethyl-6-oxo-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-2-carboxylic acid methyl ester
- Guidance literature:
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Multi-step reaction with 5 steps
1: 54 percent / hydrogen / Adams' catalyst / ethanol / 336 h
2: 90 percent / phosphorus oxychloride / pyridine
3: 1.) N-bromosuccinimide; 2.) 1,8-diazabicyclo<5.4.0>undecene-7 / 1.) CCl4; 2.) benzene
4: 85 percent / sodium methoxide / methanol
With
N-Bromosuccinimide; hydrogen; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate;
platinum(IV) oxide;
In
pyridine; methanol; ethanol;
DOI:10.1246/cl.1980.107
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73878-81-6
(4S,4aR,6R,8aS)-6-Hydroxymethyl-7-methoxymethoxy-4,8a-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-ol
- Guidance literature:
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Multi-step reaction with 9 steps
1: 80 percent / boron trifluoride / tetrahydrofuran
2: 54 percent / sodium borohydride / H2O; tetrahydrofuran
3: 1.) thionyl chloride; 2.) 1,8-diazabicyclo<5.4.0>undecene-7 / 1.) pyridine; 2.) benzene
4: acetic acid, HCl
5: 54 percent / hydrogen / Adams' catalyst / ethanol / 336 h
6: 90 percent / phosphorus oxychloride / pyridine
7: 1.) N-bromosuccinimide; 2.) 1,8-diazabicyclo<5.4.0>undecene-7 / 1.) CCl4; 2.) benzene
8: 85 percent / sodium methoxide / methanol
With
hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; boron trifluoride; hydrogen; sodium methylate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate;
platinum(IV) oxide;
In
tetrahydrofuran; pyridine; methanol; ethanol; water;
DOI:10.1246/cl.1980.107
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73878-79-2
(4aR,8R,8aS)-3-Hydroxy-4a,8-dimethyl-6-oxo-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-2-carboxylic acid methyl ester
- Guidance literature:
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Multi-step reaction with 11 steps
1: sodium hydride
2: lithium / liquid ammonia
3: 80 percent / boron trifluoride / tetrahydrofuran
4: 54 percent / sodium borohydride / H2O; tetrahydrofuran
5: 1.) thionyl chloride; 2.) 1,8-diazabicyclo<5.4.0>undecene-7 / 1.) pyridine; 2.) benzene
6: acetic acid, HCl
7: 54 percent / hydrogen / Adams' catalyst / ethanol / 336 h
8: 90 percent / phosphorus oxychloride / pyridine
9: 1.) N-bromosuccinimide; 2.) 1,8-diazabicyclo<5.4.0>undecene-7 / 1.) CCl4; 2.) benzene
10: 85 percent / sodium methoxide / methanol
With
hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; boron trifluoride; hydrogen; sodium methylate; lithium; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate;
platinum(IV) oxide;
In
tetrahydrofuran; pyridine; methanol; ethanol; ammonia; water;
DOI:10.1246/cl.1980.107
