(2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Base Information

Chemical Name:(2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol
CAS No.:138989-94-3
Molecular Formula:C₂₁H₁₉F₅N₄O₃
Molecular Weight:470.399
Hs Code.:

(2R,3R)-2-(2,4-Difluorophenyl)-3-<N-methyl-N-<4-(trifluoromethoxy)benzoyl>amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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Technology Process of (2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol

There total 2 articles about (2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 36823-88-8
4-(trifluoromethoxy)benzoyl chloride

: 138971-00-3
(2R,3R)-2-(2,4-Difluorophenyl)-3-(N-methylamino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 138989-94-3
(2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1248/cpb.39.2581

Reference yield:

: 138457-44-0
(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

: 138989-94-3
(2R,3R)-2-(2,4-Difluorophenyl)-3-amino>-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

2: 69 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.39.2581