3-<3-<2-<(N-Benzyloxycarbonyl-(S)-prolyl)amino>ethyl>-4-methoxyphenoxy>-N-tert-butoxycarbonylprolin

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Chemical Name:3-<3-<2-<(N-Benzyloxycarbonyl-(S)-prolyl)amino>ethyl>-4-methoxyphenoxy>-N-tert-butoxycarbonylprolin
CAS No.:81860-91-5
Molecular Formula:C₃₂H₄₁N₃O₉
Molecular Weight:611.692
Hs Code.:

Synonyms:

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Chemical Property of 3-<3-<2-<(N-Benzyloxycarbonyl-(S)-prolyl)amino>ethyl>-4-methoxyphenoxy>-N-tert-butoxycarbonylprolin

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Technology Process of 3-<3-<2-<(N-Benzyloxycarbonyl-(S)-prolyl)amino>ethyl>-4-methoxyphenoxy>-N-tert-butoxycarbonylprolin

There total 16 articles about 3-<3-<2-<(N-Benzyloxycarbonyl-(S)-prolyl)amino>ethyl>-4-methoxyphenoxy>-N-tert-butoxycarbonylprolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (2R,3R)-3-[3-(2-Amino-ethyl)-4-methoxy-phenoxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 3397-33-9
Z-proline N-hydroxysuccinimide ester

: 81860-91-5,81938-78-5
(2R,3R)-3-(3-{2-[((R)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-ethyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: DOI:10.1016/S0040-4039(01)92389-5

Reference yield:

: 81860-95-9
5-Hydroxy-2-methoxybenzylcyanid

: 81860-91-5,81938-78-5
(2R,3R)-3-(3-{2-[((R)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-ethyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: dimethylformamide

2: OH(-) / H₂O

3: Me₂NH*BH₃ / acetic acid

5: diethyl ether

6: OH(-) / H₂O

7: 84 percent / H₂ / Rh-Al₂O₃

8: 94 percent

With dimethylamine borane; hydroxide; hydrogen; rhodium on alumina; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)92389-5

Reference yield:

: 84923-68-2
5-(benzyloxy)-2-methoxybenzoic acid

: 81860-91-5,81938-78-5
(2R,3R)-3-(3-{2-[((R)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-ethyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: H₂ / Pd/C-5percent / ethanol

2: B₂H₆ / tetrahydrofuran

4: CH₂Cl₂

5: NH₃ / H₂O

6: dimethylformamide

7: OH(-) / H₂O

8: Me₂NH*BH₃ / acetic acid

10: diethyl ether

11: OH(-) / H₂O

12: 84 percent / H₂ / Rh-Al₂O₃

13: 94 percent

With dimethylamine borane; ammonia; hydroxide; hydrogen; diborane; palladium on activated charcoal; rhodium on alumina; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)92389-5