cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-

Base Information

Chemical Name:cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-
CAS No.:108827-41-4
Molecular Formula:C₄₄H₅₄N₈O₇
Molecular Weight:808.954
Hs Code.:

cyclo-des-Asn<sup>5</sup>,Phe<sup>6</sup><4-(3)H-Phe<sup>7</sup>,Pro<sup>12</sup>>-

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Chemical Property of cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-

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Technology Process of cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-

There total 4 articles about cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108827-31-2
Bpoc-Phe(I)-D-Trp-Lys(Boc)-Thr(t-Bu)-Phe-Pro-OH

: 108827-41-4
cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / aq. AcOH / 1 h / 50 °C

2: 72 percent / HOBt, DCC / dimethylformamide / 20 h / 50 °C

3: tritium / 10percentb Pd-C, 5percent Rh-CaCO₃ / dimethylformamide / 0.67 h / Ambient temperature

4: 90percent aq. CF₃COOH / 1 h / Ambient temperature

With tritium; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; rhodium on CaCO₃; 10% palladium on active carbon; In N,N-dimethyl-formamide;

Reference yield:

: 108827-33-4
cyclo<-Phe(I)-D-Trp-Lys(Boc)-Thr(t-Bu)-Phe-Pro->

: 108827-41-4
cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-

Guidance literature:: Multi-step reaction with 2 steps

1: tritium / 10percentb Pd-C, 5percent Rh-CaCO₃ / dimethylformamide / 0.67 h / Ambient temperature

2: 90percent aq. CF₃COOH / 1 h / Ambient temperature

With tritium; trifluoroacetic acid; rhodium on CaCO₃; 10% palladium on active carbon; In N,N-dimethyl-formamide;

Reference yield:

: 108827-32-3
H-Phe(I)-D-Trp-Lys(Boc)-Thr(t-Bu)-Phe-Pro-OH

: 108827-41-4
cyclo-des-Asn⁵,Phe⁶<4-(3)H-Phe⁷,Pro¹²>-

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / HOBt, DCC / dimethylformamide / 20 h / 50 °C

2: tritium / 10percentb Pd-C, 5percent Rh-CaCO₃ / dimethylformamide / 0.67 h / Ambient temperature

3: 90percent aq. CF₃COOH / 1 h / Ambient temperature

With tritium; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; rhodium on CaCO₃; 10% palladium on active carbon; In N,N-dimethyl-formamide;