(6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester
• CAS No.: 144262-19-1
• Molecular Formula: C₂₃H₃₀N₂O₈S
• Molecular Weight: 494.566

Synonyms:

Chemical Property of (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

There total 4 articles about (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R,7R)-4-Isopropoxy-3-methyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester → (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (144262-19-1)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 6h; Yield given; Heating;

DOI:10.3987/COM-92-6025

Reference yield:

tert-butyl-3-methyl-7-phenoxyacetamido-2-cephem-4-carboxylate (24647-38-9) → (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (144262-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / bromine, Na₂CO₃ / CH₂Cl₂ / 0.08 h / Ambient temperature

2: 65 percent / N,N-dimethylaniline / ethanol / 96 h / Ambient temperature

3: 52 percent / MCPBA, NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

4: MCPBA, NaHCO₃ / CH₂Cl₂ / 6 h / Heating

With bromine; sodium hydrogencarbonate; sodium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

DOI:10.3987/COM-92-6025

Reference yield:

(2S,3R,6R,7R)-3,4-Dibromo-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid tert-butyl ester (144262-06-6,144262-10-2) → (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (144262-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / N,N-dimethylaniline / ethanol / 96 h / Ambient temperature

2: 52 percent / MCPBA, NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

3: MCPBA, NaHCO₃ / CH₂Cl₂ / 6 h / Heating

With sodium hydrogencarbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

DOI:10.3987/COM-92-6025

upstream raw materials:

tert-butyl-3-methyl-7-phenoxyacetamido-2-cephem-4-carboxylate

(2S,3R,6R,7R)-3,4-Dibromo-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid tert-butyl ester

(6R,7R)-4-Isopropoxy-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 144262-19-1 (6R,7R)-4-Isopropoxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send