(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Base Information

Chemical Name:(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester
CAS No.:187977-15-7
Molecular Formula:C₃₄H₄₁N₇O₁₂
Molecular Weight:739.739
Hs Code.:

(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

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Chemical Property of (S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

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Technology Process of (S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

There total 3 articles about (S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 197143-02-5
(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

: 187977-15-7
(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Guidance literature:: With ethandithiol; trifluoroacetic acid; phenol; In dichloromethane; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jo961696a

Reference yield:

: 187977-05-5
(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid

: 187977-15-7
(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / EDC, HOBT, NMM / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 30 h

2: Zn / acetic acid / 24 h / Ambient temperature

3: TFA, phenol, ethanedithiol / CH₂Cl₂ / 2 h / Ambient temperature

With 4-methyl-morpholine; ethandithiol; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; zinc; phenol; In dichloromethane; acetic acid;
DOI:10.1021/jo961696a

Reference yield:

: 187977-14-6
(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

: 187977-15-7
(S)-2-[2-(2-{(S)-2-[(S)-2-((S)-2-Amino-propionyloxymethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Zn / acetic acid / 24 h / Ambient temperature

2: TFA, phenol, ethanedithiol / CH₂Cl₂ / 2 h / Ambient temperature

With ethandithiol; trifluoroacetic acid; zinc; phenol; In dichloromethane; acetic acid;
DOI:10.1021/jo961696a