Technology Process of 7-[5-(3-fluorophenyl)-3-methylisoxazol-4-yl]hept-6-ynyl-2-mercaptopropionamide
There total 6 articles about 7-[5-(3-fluorophenyl)-3-methylisoxazol-4-yl]hept-6-ynyl-2-mercaptopropionamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylsilane; trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
DOI:10.1002/cmdc.201100522
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
3: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
With
triethylsilane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1002/cmdc.201100522
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine; hydroxylamine hydrochloride; sodium sulfate / 17 h / Reflux
2: Iodine monochloride / dichloromethane / 20 °C
3: copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 130 °C / Microwave irradiation
4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
6: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
With
pyridine; triethylsilane; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; Iodine monochloride; sodium sulfate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
3: Sonogashira coupling;
DOI:10.1002/cmdc.201100522
