Technology Process of (R)-3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoic acid
There total 9 articles about (R)-3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 85 °C
2.1: potassium carbonate; ammonium hydroxide / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 80 °C / Inert atmosphere
3.1: decaborane / methanol / 18 h / 20 °C
4.1: sodium hydroxide; methanol / tetrahydrofuran / 24 h / 20 °C
4.2: pH 3
5.1: Chiralcel AS-H / isopropyl alcohol; carbon dioxide / Resolution of racemate
With
methanol; ammonium hydroxide; potassium carbonate; sodium hydroxide;
copper(l) iodide; decaborane; 4R-4-hydroxyproline;
In
tetrahydrofuran; methanol; carbon dioxide; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 50 °C
1.2: pH 5
2.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 19 h / 20 °C
3.1: decaborane / methanol / 18 h / 20 °C
4.1: sodium hydroxide; methanol / tetrahydrofuran / 24 h / 20 °C
4.2: pH 3
5.1: Chiralcel AS-H / isopropyl alcohol; carbon dioxide / Resolution of racemate
With
methanol; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
decaborane;
In
tetrahydrofuran; methanol; dichloromethane; carbon dioxide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 85 °C
2.1: potassium carbonate; ammonium hydroxide / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 80 °C / Inert atmosphere
3.1: decaborane / methanol / 18 h / 20 °C
4.1: sodium hydroxide; methanol / tetrahydrofuran / 24 h / 20 °C
4.2: pH 3
5.1: Chiralcel AS-H / isopropyl alcohol; carbon dioxide / Resolution of racemate
With
methanol; ammonium hydroxide; potassium carbonate; sodium hydroxide;
copper(l) iodide; decaborane; 4R-4-hydroxyproline;
In
tetrahydrofuran; methanol; carbon dioxide; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
