N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester
• CAS No.: 798576-71-3
• Molecular Formula: C₃₁H₃₇NO₉
• Molecular Weight: 567.636
• Mol file: 798576-71-3.mol

Synonyms:

Chemical Property of N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester

There total 1 articles about N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(2R)-3,4-dibenzyloxy-2-[(1S)-1,2-dihydroxyethyl]-2H-furan-5-one (99663-32-8) + (R)-1-Boc-nipecotic acid (163438-09-3) → N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester (798576-71-3) + (R)-Piperidine-1,3-dicarboxylic acid 3-[(S)-1-((R)-3,4-bis-benzyloxy-5-oxo-2,5-dihydro-furan-2-yl)-2-hydroxy-ethyl] ester 1-tert-butyl ester + C42H54N2O12

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2004.07.043

Reference yield: 54.0%

N-(tert-butyloxycarbonyl)piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester (798576-71-3) → piperidine-3(R)-carboxylic acid [2-(3,4-dibenzyloxy-5-oxo-2,5-dihydrofuran-2(R)-yl)-2(S)-hydroxyethyl] ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

DOI:10.1016/j.bmc.2004.07.043

upstream raw materials:

(2R)-3,4-dibenzyloxy-2-[(1S)-1,2-dihydroxyethyl]-2H-furan-5-one

(R)-1-Boc-nipecotic acid