dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine

Base Information

• Chemical Name: dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine
• CAS No.: 868074-72-0
• Molecular Formula: C₅₅H₉₅N₄O₁₂PSi₄
• Molecular Weight: 1147.69
• Mol file: 868074-72-0.mol

Synonyms:

Chemical Property of dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine

There total 4 articles about dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-5-(4'-iodobutyl)-2,4-dimethoxy-6,7-dioxopteridine (868074-70-8) + silver dibenzylphosphate (50651-75-7) → dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine (868074-72-0)

Guidance literature:

In acetonitrile; for 10h; Heating;

DOI:10.1021/jo051332v

Reference yield:

2,6-dimethoxy-5-nitro-N-((2S,3S,4R)-2,3,4,5-tetrakis(tert-butyldimethylsilyloxy)pentyl)pyrimidine-4-amine (669088-29-3) → dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine (868074-72-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / methanol / 72 h / 20 °C / 760 Torr

2.1: Et₃N / CH₂Cl₂ / 20 °C

2.2: 1.55 g / Et₃N / ethanol / 72 h / Heating

3.1: 63 percent / K₂CO₃ / acetonitrile / Heating

4.1: 70 percent / acetonitrile / 10 h / Heating

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo051332v

Reference yield:

8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopteridine (868074-69-5) → dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]butane 1-phosphateine (868074-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / K₂CO₃ / acetonitrile / Heating

2: 70 percent / acetonitrile / 10 h / Heating

With potassium carbonate; In acetonitrile;

DOI:10.1021/jo051332v

upstream raw materials:

8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-5-(4'-iodobutyl)-2,4-dimethoxy-6,7-dioxopteridine

silver dibenzylphosphate

8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopteridine

2,6-dimethoxy-5-nitro-N-((2S,3S,4R)-2,3,4,5-tetrakis(tert-butyldimethylsilyloxy)pentyl)pyrimidine-4-amine