(R)-2-Methyl-morpholine

Base Information

• Chemical Name: (R)-2-Methyl-morpholine
• CAS No.: 168038-14-0
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.609
• Hs Code.: 2934999090
• Mol file: 168038-14-0.mol

Synonyms:Morpholine,2-methyl-, hydrochloride, (R)- (9CI);

Chemical Property of (R)-2-Methyl-morpholine

Chemical Property:

• Boiling Point: 137.1ºC at 760 mmHg
• PSA: 21.26000
• Density: 0.891 g/cm3
• LogP: 0.32350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-Methyl-morpholineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-2-Methyl-morpholine hydrochloride is a reactant in the preparation of naphthyridine as hedgehog protein modulator from chloronicotinonitrile via aryl amination of naphthyridine halide.

Technology Process of (R)-2-Methyl-morpholine

There total 5 articles about (R)-2-Methyl-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-4-benzyl-2-methylmorpholine hydrochloride (845795-75-7) → (R)-(+)-2-methylmorpholine hydrochloride (168038-14-0,59229-57-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; at 20 ℃; under 760.051 Torr;

Reference yield: 84.0%

4-benzyl-2-methyl-morpholine (32730-38-4) → 2-methylmorpholine hydrochloride (168038-14-0,59229-57-1)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

(S)-2-methyl-4-(4-nitrobenzenesulfonyl)morpholine → (2S)-2-methylmorpholine hydrochloride (1147108-99-3,168038-14-0,59229-57-1)

Guidance literature:

(S)-2-methyl-4-(4-nitrobenzenesulfonyl)morpholine; With lithium hydroxide monohydrate; 1-thiopropane; In acetonitrile; at 20 ℃;

With hydrogenchloride; In methanol; acetonitrile;

upstream raw materials:

4-benzyl-2-methyl-morpholine

(R)-4-benzyl-2-methylmorpholine hydrochloride

(R)-1-(benzyl(2-hydroxyethyl)amino)propan-2-ol

Downstream raw materials:

N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-methylmorpholino)pyrido[3,4-d]pyrimidin-2-amine

Refernces

• 1、 -. "CHROMENONE COMPOUNDS AS PI 3 -KINASE INHIBITORS FOR THE TREATMENT OF CANCER". Page/Page column 143. . Retrieved 2012/11/06.
• 2、 -. "THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS". Page/Page column 47. . Retrieved 2010/12/18.