Technology Process of (6E,8E,10E,12E)-(S)-15-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-5-oxo-hexadeca-6,8,10,12-tetraenoic acid methyl ester
There total 16 articles about (6E,8E,10E,12E)-(S)-15-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-5-oxo-hexadeca-6,8,10,12-tetraenoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 80 percent / porcine liver esterase, Na2HPO4, H2O / 12 h / Ambient temperature
2: 95 percent / imidazole, DMAP / CH2Cl2 / 6 h / Ambient temperature
3: 80 percent / KOH, H2O / 2-methyl-propan-2-ol / 2 h / 50 °C
4: 1.) carbonyldiimidazole / 1.) THF, rt, 3 h, 2.) rt, 12 h
6: 80 percent / Hg(OOCCF3)2 / tetrahydrofuran / 24 h / Ambient temperature
7: 65 percent / BH3-THF / tetrahydrofuran / 4 h / Ambient temperature
8: 85 percent / PCC, NaOAc / CH2Cl2 / 6 h / Ambient temperature
9: 99 percent / NaH / 0.08 h / Ambient temperature
10: 60 percent / H2O, pyridinium p-toluenesulfonate / methanol / 16 h / Heating
With
1H-imidazole; porcine liver esterase; dmap; potassium hydroxide; disodium hydrogenphosphate; borane-THF; water; sodium acetate; mercury(II) trifluoroacetate; pyridinium p-toluenesulfonate; sodium hydride; 1,1'-carbonyldiimidazole; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)88094-6
- Guidance literature:
-
Multi-step reaction with 4 steps
1: PCC, NaOAc / CH2Cl2 / 6 h / Ambient temperature
2: benzene / 24 h / Heating
3: benzene / 24 h / Heating
With
sodium acetate; pyridinium chlorochromate;
In
dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)88094-6
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / NaH / 0.08 h / Ambient temperature
2: 60 percent / H2O, pyridinium p-toluenesulfonate / methanol / 16 h / Heating
With
water; pyridinium p-toluenesulfonate; sodium hydride;
In
methanol;
DOI:10.1016/S0040-4039(00)88094-6
