Technology Process of 5-{5-[3-(2,4-Dimethyl-phenyl)-propyl]-thiophen-2-yl}-3-methyl-pentanoic acid
There total 5 articles about 5-{5-[3-(2,4-Dimethyl-phenyl)-propyl]-thiophen-2-yl}-3-methyl-pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; potassium hydroxide; hydrazine;
Multistep reaction;
1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: p-toluene sulfonic acid / 20 h / Heating
2: 1.) SOCl2, 2.) SnCl4 / 1.) 40 deg C, half an h., 2.) CH2Cl2, 0 deg C, 30 min, room temp.
3: 1.) NH2-NH2, KOH, 2.) aq.HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.
With
hydrogenchloride; potassium hydroxide; thionyl chloride; tin(IV) chloride; toluene-4-sulfonic acid; hydrazine;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NH2-NH2, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 210 deg C, 1 h, 2.) room temp.
2: p-toluene sulfonic acid / 20 h / Heating
3: 1.) SOCl2, 2.) SnCl4 / 1.) 40 deg C, half an h., 2.) CH2Cl2, 0 deg C, 30 min, room temp.
4: 1.) NH2-NH2, KOH, 2.) aq.HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.
With
hydrogenchloride; potassium hydroxide; thionyl chloride; tin(IV) chloride; toluene-4-sulfonic acid; hydrazine;