Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester
CAS No.:233756-58-6
Molecular Formula:C₂₇H₂₆N₈O₁₁
Molecular Weight:638.55
Hs Code.:

Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

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Chemical Property of Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

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Technology Process of Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

There total 1 articles about Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 23945-44-0,76821-79-9
2,4-dihydroxypyrimidine-5-carboxylic acid

: 108310-92-5
2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate

: 233756-58-6
Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; lithium chloride; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4039(99)00857-6

Reference yield:

: 233756-58-6
Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

: 233756-54-2
2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid {9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-amide

Guidance literature:: With ammonia; In methanol; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(99)00857-6

Reference yield:

: 233756-58-6
Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

: Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-hydroxy-purin-9-yl}-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / DBU, CH₃CN

2: Et₃N, DMAP / CH₂Cl₂

3: 1H-tetrazole, mol. sieves 4 Angstroem / acetonitrile

With 1H-tetrazole; dmap; 4 A molecular sieve; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; acetonitrile; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(99)00857-6