2-(Chloromethyl)-4-ethoxypyridine

Base Information

Chemical Name:2-(Chloromethyl)-4-ethoxypyridine
CAS No.:159996-13-1
Molecular Formula:C8H10ClNO
Molecular Weight:171.626
Hs Code.:
DSSTox Substance ID:DTXSID10568762
Wikidata:Q72453956
Mol file:159996-13-1.mol

Synonyms:2-(CHLOROMETHYL)-4-ETHOXYPYRIDINE;159996-13-1;SCHEMBL3641525;DTXSID10568762;QXHKPITWPCZGSB-UHFFFAOYSA-N;AKOS010506138

Suppliers and Price of 2-(Chloromethyl)-4-ethoxypyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
2-(chloromethyl)-4-ethoxy-Pyridinehydrochloride 97.00%
25G
$ 8510.00

AccelPharmtech
2-(chloromethyl)-4-ethoxy-Pyridinehydrochloride 97.00%
5G
$ 4530.00

AccelPharmtech
2-(chloromethyl)-4-ethoxy-Pyridinehydrochloride 97.00%
1G
$ 2640.00

Total 7 raw suppliers

Chemical Property of 2-(Chloromethyl)-4-ethoxypyridine

Chemical Property:

Vapor Pressure:0.0253mmHg at 25°C
Refractive Index:1.514
Boiling Point:256 °C at 760 mmHg
PKA:5.02±0.20(Predicted)
Flash Point:108.6 °C
PSA：22.12000
Density:1.137 g/cm³
LogP:2.21910
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:171.0450916
Heavy Atom Count:11
Complexity:110

Purity/Quality:

99% ^*data from raw suppliers

2-(chloromethyl)-4-ethoxy-Pyridinehydrochloride 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC(=NC=C1)CCl

Technology Process of 2-(Chloromethyl)-4-ethoxypyridine

There total 3 articles about 2-(Chloromethyl)-4-ethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19677-69-1
(4-ethoxypyridin-2-yl)methanol

: 159996-13-1
2-(chloromethyl)-4-ethoxypyridine

Guidance literature:: With thionyl chloride; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/jm00081a004

Reference yield:

: 26883-31-8
4-ethoxy-2-methyl-pyridine-1-oxide

: 159996-13-1
2-(chloromethyl)-4-ethoxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / 120 °C

2: 2N aq. NaOH / methanol / 2 h / 25 °C

3: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; acetic acid; In methanol; dichloromethane;
DOI:10.1021/jm00081a004

Reference yield:

: Acetic acid 4-ethoxy-pyridin-2-ylmethyl ester

: 159996-13-1
2-(chloromethyl)-4-ethoxypyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 2N aq. NaOH / methanol / 2 h / 25 °C

2: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;
DOI:10.1021/jm00081a004