HCl-Val-Pyrrolidide

Base Information

• Chemical Name: HCl-Val-Pyrrolidide
• CAS No.: 115201-28-0
• Molecular Formula: C₉H₁₈N₂O*ClH
• Molecular Weight: 206.716
• Mol file: 115201-28-0.mol

Synonyms:

Chemical Property of HCl-Val-Pyrrolidide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(2S)-2-Amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-onehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HCl-Val-Pyrrolidide

There total 1 articles about HCl-Val-Pyrrolidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(S)-tert-butyl 3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate (130013-62-6) → Valine-pyrrolidine hydrochloride (115201-28-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/jm00115a001

Reference yield:

Valine-pyrrolidine hydrochloride (115201-28-0) → 2-(3,4-dichlorophenyl)-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide (115200-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.65 g / CH₂Cl₂ / 2 h / 20 °C

2: BH₃ / tetrahydrofuran / 3 h / Heating

With borane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00115a001

Reference yield:

Valine-pyrrolidine hydrochloride (115201-28-0) → 2-(3,4-dichlorophenyl)-N-ethyl-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide (115200-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2: 0.67 g / LAH / tetrahydrofuran / 72 h / 20 °C

3: 43 percent / CH₂Cl₂ / 2 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00115a001

upstream raw materials:

(S)-tert-butyl 3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate

Downstream raw materials:

2-(3,4-Dichloro-phenyl)-N-[(S)-2-methyl-1-(pyrrolidine-1-carbonyl)-propyl]-acetamide

2-(3,4-dichlorophenyl)-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide

2-(3,4-dichlorophenyl)-N-ethyl-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide

2-(3,4-dichlorophenyl)-N-propyl-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide