Technology Process of (2E,4E,7R,2'R,3'R)-11-<4'-Oxo-3'-(triphenylmethoxymethyl)-2'-oxetanyl>-3,5,7-trimethyl-2,4-undecadienoic acid
There total 18 articles about (2E,4E,7R,2'R,3'R)-11-<4'-Oxo-3'-(triphenylmethoxymethyl)-2'-oxetanyl>-3,5,7-trimethyl-2,4-undecadienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) KH / 1) THF, mineral oil, r.t., 15 min, 2) THF, 40 deg C, 2 d
2: 75 percent / 1 M tetra(n-butyl)ammonium fluoride / tetrahydrofuran / 3 h / 0 °C
3: 1a) oxalyl chloride, DMSO, 2) Et3N / 1a) CH2Cl2, -78 deg C, 15 min, b) -78 deg C, 1 h, 2) -78 to 0 deg C
4: 95 percent / NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 0.5 h / Ambient temperature
5: Amberlyst-15 / methanol / 12 h / Ambient temperature
6: 85 percent / pyridine / 12 h / 70 °C
7: 0.3 N aq.LiOH / tetrahydrofuran / 120 h / 30 °C
8: benzenesulfonyl chloride, pyridine / 12 h / 0 °C
With
pyridine; lithium hydroxide; sodium chlorite; sodium dihydrogenphosphate; amberlyst-15; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium hydride; dimethyl sulfoxide; triethylamine; benzenesulfonyl chloride;
In
tetrahydrofuran; methanol; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) KH / 1) THF, mineral oil, r.t., 15 min, 2) THF, 40 deg C, 2 d
2: 75 percent / 1 M tetra(n-butyl)ammonium fluoride / tetrahydrofuran / 3 h / 0 °C
3: 1a) oxalyl chloride, DMSO, 2) Et3N / 1a) CH2Cl2, -78 deg C, 15 min, b) -78 deg C, 1 h, 2) -78 to 0 deg C
4: 95 percent / NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 0.5 h / Ambient temperature
5: Amberlyst-15 / methanol / 12 h / Ambient temperature
6: 85 percent / pyridine / 12 h / 70 °C
7: 0.3 N aq.LiOH / tetrahydrofuran / 120 h / 30 °C
8: benzenesulfonyl chloride, pyridine / 12 h / 0 °C
With
pyridine; lithium hydroxide; sodium chlorite; sodium dihydrogenphosphate; amberlyst-15; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium hydride; dimethyl sulfoxide; triethylamine; benzenesulfonyl chloride;
In
tetrahydrofuran; methanol; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / pyridine / 12 h / 70 °C
2: 0.3 N aq.LiOH / tetrahydrofuran / 120 h / 30 °C
3: benzenesulfonyl chloride, pyridine / 12 h / 0 °C
With
pyridine; lithium hydroxide; benzenesulfonyl chloride;
In
tetrahydrofuran;
